Evidence map›Paper›PMID 25176067›Full record

ArticleBiomaterials2014

Rapidly polymerizing injectable click hydrogel therapy to delay bone growth in a murine re-synostosis model.

Christopher D Hermann, David S Wilson, Kelsey A Lawrence, Xinghai Ning, Rene Olivares-Navarrete, Joseph K Williams, Robert E Guldberg, Niren Murthy, Zvi Schwartz, Barbara D Boyan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Smart responsiveFrontiers in bioengineering and biotechnology · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Signaling Mechanisms Underlying Genetic Pathophysiology of Craniosynostosis.International journal of biological sciences · 2019
    Review
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Christopher D HermannWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA; Emory University School of Medicine, Atlanta, GA, USA.
David S WilsonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA.
Kelsey A LawrenceWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA.
Xinghai NingWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA.
Rene Olivares-NavarreteDepartment of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
Joseph K WilliamsChildren's Healthcare of Atlanta, Atlanta, GA, USA.
Robert E GuldbergWoodruff School of Mechanical Engineering, Georgia Institute of Technology Atlanta, GA, USA.
Niren MurthyDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA, USA. Electronic address: nmurthy@berkeley.edu.
Zvi SchwartzDepartment of Bioengineering, University of California at Berkeley, Berkeley, CA, USA.
Barbara D BoyanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology Atlanta, GA, USA; Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: bboyan@vcu.edu.
Georgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · USUniversity of California, Berkeley · USChildren's Healthcare of Atlanta · USEmory University · USVirginia Commonwealth University · US

Funding

ATLANTIC PEDIATRIC DEVICE CONSORTIUMP50FD004193 · FDA · GEORGIA INSTITUTE OF TECHNOLOGY · PI KU, DAVID N · 2011 to 2017
$5.7M
Plaque detection with the hydrocyaninesR01HL096796 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI MURTHY, NIREN · 2009 to 2013
$1.8M
Spatiotemporal control of reactive oxygen species in T cellsR01AI088023 · NIAID · GEORGIA INSTITUTE OF TECHNOLOGY · PI KEMP, MELISSA LAMBETH · 2011 to 2014
$1.4M
FDA HHS P50 FD004193NHLBI NIH HHS HHSN268201000043CNHLBI NIH HHS R01 HL096796NHLBI NIH HHS R01HL096796-04NIAID NIH HHS R01 AI088023NIAID NIH HHS R01AI088023-03
6 · The paper itself

Abstract

Craniosynostosis is the premature fusion of cranial sutures, which can result in progressive cranial deformations, increased intracranial pressure, and restricted brain growth. Most cases of craniosynostosis require surgical reconstruction of the cranial vault with the goal of increasing the intracranial volume and correcting the craniofacial deformities. However, patients often experience rapid post-operative bone regrowth, known as re-synostosis, which necessitates additional surgical intervention. Bone morphogenetic protein (BMP) inhibitors have tremendous potential to treat re-synostosis, but the realization of a clinically viable inhibitor-based therapeutic requires the development of a delivery vehicle that can localize the release to the site of administration. Here, we present an in situ rapidly crosslinking injectable hydrogel that has the properties necessary to encapsulate co-administered proteins and demonstrate that the delivery of rmGremlin1 via our hydrogel system delays bone regrowth in a weanling mouse model of re-synostosis. Our hydrogel is composed of two mutually reactive poly(ethylene glycol) macromolecules, which when mixed crosslink via a bio-orthogonal Cu free click reaction. Hydrogels containing Gremlin caused a dose dependent inhibition of bone regrowth. In addition to craniofacial applications, our injectable click hydrogel has the potential to provide customizable protein, small molecule, and cell delivery to any site accessible via needle or catheter.

Indexed as

AnimalsBone DevelopmentClick ChemistryCopperCraniosynostosesCytokinesDrug CarriersHydrogel, Polyethylene Glycol DimethacrylateInjectionsIntercellular Signaling Peptides and ProteinsMaleMiceMice, Inbred C57BLPolyethylene GlycolsPolymerizationCopperCytokinesDrug CarriersGrem1 protein, mouseHydrogel, Polyethylene Glycol DimethacrylateIntercellular Signaling Peptides and ProteinsPolyethylene GlycolsBMP (bone morphogenetic protein)Bone ingrowthCraniosynostosisHydrogelRe-synostosis

Identifiers

PMID25176067
PMCPMC4217121
OpenAlexW2057239555

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.