Evidence map›Paper›PMID 25176041›Full record

ArticleBMC cancer2014

High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients.

Jia-Hui Qi, Jin Wang, Jinyun Chen, Fan Shen, Jing-Tao Huang, Subrata Sen, Xin Zhou, Song-Mei Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 7 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 7 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  5. [Association between miR-146a single nucleotide polymorphism and genetic susceptibility to hepatocellular carcinoma: a meta-analysis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2017
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  7. Effect ofTechnology in cancer research & treatment
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  18. Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
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  19. Article
  20. MicroRNA as Biomarkers and Diagnostics.Journal of cellular physiology · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jia-Hui Qi
Jin Wang
Jinyun Chen
Fan Shen
Jing-Tao Huang
Subrata Sen
Xin Zhou
Song-Mei LiuCenter for Gene Diagnosis, Medical Research Center, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei 430071, China. smliu@whu.edu.cn.
The University of Texas MD Anderson Cancer Center · USZhongnan Hospital of Wuhan University · CNWuhan University · CN

Funding

Biomarkers for the Early Detection of Pancreatic CancerU01CA111302 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KILLARY, ANN M, SEN, SUBRATA · 2004 to 2015
$6.6M
NCI NIH HHS U01 CA111302NCI NIH HHS UO1CA111302
6 · The paper itself

Abstract

backgroundAlthough several single-nucleotide polymorphisms in microRNA (miRNA) genes have been associated with primary hepatocellular carcinoma, published findings regarding this relationship are inconsistent and inconclusive.

methodsThe high-resolution melting (HRM) analysis was used to determine whether the occurrence of the SNPs of miR-146a C > G (rs2910164), miR-196a2 C > T (rs11614913), miR-301b A > G (rs384262), and miR-499 C > T (rs3746444) differs in frequency-matched 314 HCC patients and 407 controls by age and sex.

resultsThe groups' genotype distributions of miR-196a2 C > T and miR-499 C > T differed significantly (P < 0.01), both of them increased the risk of HCC in different dominant genetic models (P < 0.01); compared with individuals carrying one or neither of the unfavorable genotypes, individuals carrying both unfavorable genotypes (CT + CC) had a 3.11-fold higher HCC risk (95% confidence interval (CI), 1.89-5.09; P = 7.18 × 10-6). Moreover, the allele frequency of miR-499 C > T was significantly different between the two groups, and the HCC risk of carriers of the C allele was higher than that of carriers of the T allele (odds ratio, 1.53; 95% CI, 1.15-2.03; P = 0.003). Further, we found that the activated partial thromboplastin time (APTT) in HCC patients with miR-196a2 CC genotype was longer than patients with TT genotypes (P < 0.05), and HCC patients with miR-499 C allele had higher serum levels of direct bilirubin, globulin, γ-glutamyltranspeptidase, alkaline phosphatase, and lower serum cholinesterase (P < 0.05).

conclusionsOur findings suggest that the SNPs in miR-196a2 C > T and miR-499 C > T confer HCC risk and that affect the clinical laboratory characteristics of HCC patients.

Indexed as

Asian PeopleCarcinoma, HepatocellularCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansLiver NeoplasmsMaleMicroRNAsPolymorphism, Single NucleotideSequence Analysis, DNAMicroRNAsMIRN146 microRNA, humanMIRN196 microRNA, humanMIRN301A microRNA, humanMIRN499 microRNA, human

Identifiers

PMID25176041
PMCPMC4161871
OpenAlexW2043316559

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.