ArticleBMC cancer2014
The association of time between diagnosis and major resection with poorer colorectal cancer survival: a retrospective cohort study.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 6 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 6 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Pooled it
- Clinical Delays and Comparative Outcomes in Younger and Older Adults with Colorectal Cancer: A Systematic Review.Current oncology (Toronto, Ont.) · 2022Pooled it
- Time to diagnosis and treatment in younger adults with colorectal cancer: A systematic review.PloS one · 2022Pooled it
- The Association Between Treatment Interval and Survival in Patients With Colon or Rectal Cancer: A Systematic Review.World journal of surgery · 2021Pooled it
- Conflicting Guidelines: A Systematic Review on the Proper Interval for Colorectal Cancer Treatment.World journal of surgery · 2021Pooled it
- Adherence in the Cancer Care Setting: a Systematic Review of Patient Navigation to Traverse Barriers.Journal of cancer education : the official journal of the American Association for Cancer Education · 2018Pooled it
- Influence of Diagnostic and Treatment Delays on Survival Outcomes in Patients With Locally Advanced Rectal Cancer: A Multi-Center Retrospective Cohort Study.Cancer medicine · 2026Article
- Treatment interval in curative treatment of colon cancer, does it impact (cancer free) survival? A non-inferiority analysis.British journal of cancer · 2024Article
- Near-infrared fluorescence tattooing: a new approach for endoscopic marking of tumors in minimally invasive colorectal surgery using a persistent near-infrared marker.Surgical endoscopy · 2023Article
- Recurrence and Postoperative Death in Patients with Colorectal Cancer: A New Perspective via Semi-competing Risk Framework.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- The prognostic impact of lead times in colorectal cancer patients undergoing cytoreductive surgery and HIPEC.World journal of surgical oncology · 2022Review
- Longer time-to-treatment but better survival for colorectal cancer patients presumptively not diagnosed in a hospital.Cancer causes & control : CCC · 2021Article
- Preoperative endoscopic marking of the gastrointestinal tract using fluorescence imaging: submucosal indocyanine green tattooing versus a novel fluorescent over-the-scope clip in a survival experimental study.Surgical endoscopy · 2021Article
- Colorectal Cancer Surgery Quality in Manitoba: A Population-Based Descriptive Analysis.Current oncology (Toronto, Ont.) · 2021Article
- Article
- Use of the English urgent referral pathway for suspected cancer and mortality in patients with cancer: cohort study.BMJ (Clinical research ed.) · 2015Article
- A differentiated approach to referrals from general practice to support early cancer diagnosis - the Danish three-legged strategy.British journal of cancer · 2015Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundColorectal cancer survival in the UK is lower than in other developed countries, but the association of time interval between diagnosis and treatment on excess mortality remains unclear.
methodsUsing data from cancer registries in England, we identified 46,511 patients with localised colorectal cancer between 1996-2009, who were 15 years and older, and who underwent a major surgical resection within 62 days of diagnosis. We used relative survival and excess risk modeling to investigate the association of time between diagnosis and major resection (exposure) with survival (outcome).
resultsCompared to patients who had major resection within 25-38 days of diagnosis, patients with a shorter time interval between diagnosis and resection and those waiting longer for resection had higher excess mortality (Excess Hazards Ratio, EHR <25 vs 25-38 days: 1.50; 95% Confidence Interval, CI: 1.37 to 1.66; EHR 39-62 vs 25-38 days : 1.16; 95% CI: 1.04 to 1.29). Excess mortality was associated with age (EHR 75+ vs. 15-44 year olds: 2.62; 95% CI: 2.00 to 3.42) and deprivation (EHR most vs. least deprived: 1.27; 95% CI: 1.12 to 1.45), but time between diagnosis and resection did not explain these differences.
conclusionWithin 62 days of diagnosis, a U-shaped association of time between diagnosis and major resection with excess mortality for localised colorectal cancer was evident. This indicates a complicated treatment pathway, particularly for patients who had resection earlier than 25 days, and requires further investigation.
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