Evidence map›Paper›PMID 25175449›Full record

ReviewHemodialysis international. International Symposium on Home Hemodialysis2015

Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature.

Lin Li, Mark Fisher, Wei-Ling Lau, Hamid Moradi, Alexander Cheung, Gaby Thai, Jason Handwerker, Kamyar Kalantar-Zadeh

Abstract readCase ReportsReview
In one paragraph

Review in Hemodialysis international. International Symposium on Home Hemodialysis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Review
  4. Mechanisms of Cerebral Microvascular Disease in Chronic Kidney Disease.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lin LiDivision of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, U.S.A.
Mark FisherDepartment of Neurology, University of California Irvine School of Medicine, Orange, California, U.S.A.
Wei-Ling LauDivision of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, U.S.A.
Hamid MoradiDivision of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, U.S.A.
Alexander CheungDivision of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, U.S.A.
Gaby ThaiDepartment of Neurology, University of California Irvine School of Medicine, Orange, California, U.S.A.
Jason HandwerkerDepartment of Radiological Sciences, University of California Irvine School of Medicine, Orange, California, U.S.A.
Kamyar Kalantar-ZadehDivision of Nephrology and Hypertension, University of California Irvine School of Medicine, Orange, California, U.S.A.
University of California, Irvine · US

Funding

HEMORHOLOGICAL FACTORS IN CEREBRAL ISCHEMIAR01NS020989 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIBBS, DAVID HASTINGS, FISHER, MARK J · 1985 to 2022
$9.1M
MALNUTRITION, DIET AND RACIAL DISPARITIES IN CKDK24DK091419 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI KALANTAR-ZADEH, KAMYAR · 2011 to 2020
$1.8M
NIDDK NIH HHS K24 DK091419NINDS NIH HHS NS020989NINDS NIH HHS R01 NS020989
6 · The paper itself

Abstract

Cerebral microbleeds (CMBs) are small hemosiderin deposits indicative of prior cerebral microscopic hemorrhage and previously thought to be clinically silent. Recent population-based cross-sectional studies and prospective longitudinal cohort studies have revealed association between CMB and cognitive dysfunction. In the general population, CMBs are associated with age, hypertension, and cerebral amyloid angiopathy. In the chronic kidney disease (CKD) population, diminished estimated glomerular filtration rate has been found to be an independent risk factor for CMB, raising the possibility that a uremic milieu may predispose to microbleeds. In the end-stage renal disease (ESRD) population on hemodialysis, the incidence of microbleeds is significantly higher compared with a control group without history of CKD or stroke. We present an ESRD patient on chronic hemodialysis with a history of gradual cognitive decline and progressive CMBs. Through this case and literature review, we illustrate the need to develop detection and prediction models to treat this frequent development in ESRD patients.

Indexed as

AgedCerebral HemorrhageCognition DisordersFemaleHumansMagnetic Resonance ImagingRenal DialysisRenal Insufficiency, Chroniccerebral microbleedscognitive declinedementiaDialysisuremia

Identifiers

PMID25175449
PMCPMC4345139
OpenAlexW1523317666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.