ArticleEnvironmental science and pollution research international2016
Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 72 citations in OpenAlex.
- Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Developmental and toxicological effects of butylated hydroxytoluene metabolites on zebrafish larvae.Scientific reports · 2025Article
- Computational Study of Photodegradation Process and Conversion Products of the Antidepressant Citalopram in Water.Molecules (Basel, Switzerland) · 2023Article
- Comparison of anxiety-like and social behaviour in medaka and zebrafish.Scientific reports · 2022Article
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- Development of Open-Field Behaviour in the Medaka,Biology · 2020Article
- Divergent Response to the SSRI Citalopram in Male and Female Three-Spine Sticklebacks (Gasterosteus aculeatus).Archives of environmental contamination and toxicology · 2020Article
- Environmental risk assessment of psychoactive drugs in the aquatic environment.Environmental science and pollution research international · 2019Review
- Evaluation of psychiatric hospital wastewater toxicity: what is its impact on aquatic organisms?Environmental science and pollution research international · 2018Article
- Psychoactive drugs: occurrence in aquatic environment, analytical methods, and ecotoxicity-a review.Environmental science and pollution research international · 2017Review
- De novo transcriptome sequencing and analysis of freshwater snail (Radix balthica) to discover genes and pathways affected by exposure to oxazepam.Ecotoxicology (London, England) · 2017Article
- Studies on photodegradation process of psychotropic drugs: a review.Environmental science and pollution research international · 2017Review
- Pharmaceutical Residues Affecting the UNESCO Biosphere Reserve Kristianstads Vattenrike Wetlands: Sources and Sinks.Archives of environmental contamination and toxicology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychiatric pharmaceuticals, such as anxiolytics, sedatives, hypnotics and antidepressors, are among the most prescribed active substances in the world. The occurrence of these compounds in the environment, as well as the adverse effects they can have on non-target organisms, justifies the growing concern about these emerging environmental pollutants. This study aims to analyse the effects of six psychotropic drugs, valproate, cyamemazine, citalopram, sertraline, fluoxetine and oxazepam, on the survival and locomotion of Japanese medaka Oryzias latipes larvae. Newly hatched Japanese medaka were exposed to individual compounds for 72 h, at concentrations ranging from 10 μg L(-1) to 10 mg L(-1). Lethal concentrations 50 % (LC50) were estimated at 840, 841 and 9,136 μg L(-1) for fluoxetine, sertraline and citalopram, respectively, while other compounds did not induce any significant increase in mortality. Analysis of the swimming behaviour of larvae, including total distance moved, mobility and location, provided an estimated lowest observed effect concentration (LOEC) of 10 μg L(-1) for citalopram and oxazepam, 12.2 μg L(-1) for cyamemazine, 100 μg L(-1) for fluoxetine, 1,000 μg L(-1) for sertraline and >10,000 μg L(-1) for valproate. Realistic environmental mixture of the six psychotropic compounds induced disruption of larval locomotor behaviour at concentrations about 10- to 100-fold greater than environmental concentrations.
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Registered trials
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