ArticleCancer letters2014
BAG3 down-modulation sensitizes HPV18(+) HeLa cells to PEITC-induced apoptosis and restores p53.
Article in Cancer letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Extraction and Purification of a Melanin fromMicroorganisms · 2026Article
- Article
- An emerging role for BAG3 in gynaecological malignancies.British journal of cancer · 2021Review
- Advances in the role and mechanism of BAG3 in dilated cardiomyopathy.Heart failure reviews · 2021Review
- Silk Sericin Hydrolysate is a Potential Candidate as a Serum-Substitute in the Culture of Chinese Hamster Ovary and Henrietta Lacks Cells.Journal of insect science (Online) · 2019Article
- Down-regulation of BAG3 inhibits proliferation and promotes apoptosis of glioblastoma multiforme through BAG3/HSP70/HIF-1α signaling pathway.International journal of clinical and experimental pathology · 2018Article
- BAG3 Protein Is Involved in Endothelial Cell Response to Phenethyl Isothiocyanate.Oxidative medicine and cellular longevity · 2018Article
- Systematic evaluation of sericin protein as a substitute for fetal bovine serum in cell culture.Scientific reports · 2016Article
- Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.Cell death & disease · 2015Article
- Phosphorus-32, a clinically available drug, inhibits cancer growth by inducing DNA double-strand breakage.PloS one · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
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Abstract
BAG3 is a multi-functional component of tumor cell pro-survival machinery, and its biological functions have been largely associated to proteasome system. Here, we show that BAG3 down-modulation resulted in reduced cell viability and enhanced PEITC-induced apoptosis largely more extensively in HeLa (HPV18(+)) rather than in C33A (HPV(-)) cervical carcinoma cell lines. Moreover, we demonstrate that BAG3 suppression led to a decrease of viral E6 oncoprotein and a concomitant recovery of p53 tumor suppressor, the best recognized target of E6 for proteasome degradation. E6 and p53 expression were modulated at protein level, since their respective mRNAs were unaffected. Taken together our findings reveal a novel role for BAG3 as host protein contributing to HPV18 E6-activated pro-survival strategies, and suggest a possible relevance of its expression levels in drug/radiotherapy-resistance of HPV18-bearing cervical carcinomas.
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