Trial reportThe Journal of allergy and clinical immunology2015
Efficacy of nasal mometasone for the treatment of chronic sinonasal disease in patients with inadequately controlled asthma.
Trial report in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Intranasal steroids versus placebo or no intervention for chronic rhinosinusitis.The Cochrane database of systematic reviews · 2016Pooled it
- Roflumilast May Increase Risk of Exacerbations When Used to Treat Poorly Controlled Asthma in People with Obesity.Annals of the American Thoracic Society · 2023Trial
- An Online Weight Loss Intervention for People With Obesity and Poorly Controlled Asthma.The journal of allergy and clinical immunology. In practice · 2022Trial
- Effect of obesity on sinonasal disease in asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2018Trial
- Effect of intranasal corticosteroids on allergic airway disease in asthma.The journal of allergy and clinical immunology. In practiceTrial
- Comorbid Chronic Rhinosinusitis and Asthma: Shared Risk Factors and Treatment Implications-An EAACI Task Force Report.Allergy · 2026Article
- The effects of the DASH dietary pattern on clinical outcomes and quality of life in adults with uncontrolled asthma: Design and methods of the ALOHA Trial.Contemporary clinical trials · 2023Article
- The Role of Comorbidities in Difficult-to-Control Asthma in Adults and Children.The journal of allergy and clinical immunology. In practice · 2022Article
- Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.Respirology (Carlton, Vic.) · 2019Article
- BMI but not central obesity predisposes to airway closure during bronchoconstriction.Respirology (Carlton, Vic.) · 2019Article
- Asthma and Chronic Rhinosinusitis: Diagnosis and Medical Management.Medical sciences (Basel, Switzerland) · 2019Review
- Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?The journal of allergy and clinical immunology. In practice · 2019Observational
- Current opinions for the management of asthma associated with ear, nose and throat comorbidities.European respiratory review : an official journal of the European Respiratory Society · 2018Review
- Sino-Nasal 5 Questionnaire is Associated with Poor Asthma Control in Children with Asthma.Children (Basel, Switzerland) · 2017Article
- Challenges in the Management of Asthma in the Elderly.Allergy, asthma & immunology research · 2015Review
- Reply: To PMID 25174863.The Journal of allergy and clinical immunology · 2015Article
- Functional significance of 8-isoprostanes in sinonasal disease and asthma.Respiratory medicineArticle
- The Saudi initiative for asthma - 2024 update: Guidelines for the diagnosis and management of asthma in adults and children.Annals of thoracic medicineArticle
- Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis.American journal of rhinology & allergyReview
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundChronic sinonasal disease is common in asthmatic patients and associated with poor asthma control; however, there are no long-term trials addressing whether chronic treatment of sinonasal disease improves asthma control.
objectiveWe sought to determine whether treatment of chronic sinonasal disease with nasal corticosteroids improves asthma control, as measured by the Childhood Asthma Control Test and Asthma Control Test in children and adults, respectively.
methodsA 24-week multicenter, randomized, placebo-controlled, double-blind trial of placebo versus nasal mometasone in adults and children with inadequately controlled asthma was performed. Treatments were randomly assigned, with concealment of allocation.
resultsTwo hundred thirty-seven adults and 151 children were randomized to nasal mometasone versus placebo, and 319 participants completed the study. There was no difference in the Childhood Asthma Control Test score (difference in change with mometasone - change with placebo [ΔM - ΔP], -0.38; 95% CI, -2.19 to 1.44; P = .68; age 6-11 years) or the Asthma Control Test score (ΔM - ΔP, 0.51; 95% CI, -0.46 to 1.48; P = .30; age ≥12 years) in those assigned to mometasone versus placebo. In children and adolescents (age 6-17 years) there was no difference in asthma or sinus symptoms but a decrease in episodes of poorly controlled asthma defined by a decrease in peak flow. In adults there was a small difference in asthma symptoms measured by using the Asthma Symptom Utility Index (ΔM - ΔP, 0.06; 95% CI, 0.01 to 0.11; P < .01) and in nasal symptoms (sinus symptom score ΔM - ΔP, -3.82; 95% CI, -7.19 to -0.45; P = .03) but no difference in asthma quality of life, lung function, or episodes of poorly controlled asthma in adults assigned to mometasone versus placebo.
conclusionsTreatment of chronic sinonasal disease with nasal corticosteroids for 24 weeks does not improve asthma control. Treatment of sinonasal disease in asthmatic patients should be determined by the need to treat sinonasal disease rather than to improve asthma control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.