Evidence map›Paper›PMID 25174686›Full record

ArticlePsychophysiology2015

Resting high-frequency heart rate variability is related to resting brain perfusion.

Ben Allen, J Richard Jennings, Peter J Gianaros, Julian F Thayer, Stephen B Manuck

Abstract read
In one paragraph

Article in Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Prediction model for mild cognitive impairment in patients with type 2 diabetes using the autonomic function test.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  6. Article
  7. Depression of dynamic cerebral autoregulation during neural activation: The role of responders and non-responders.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  8. Article
  9. Sympathetic and parasympathetic central autonomic networks.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ben AllenDepartment of Psychiatry and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
J Richard Jennings
Peter J Gianaros
Julian F Thayer
Stephen B Manuck
University of Pittsburgh · USThe Ohio State University · US

Funding

Substrates of Threat and Reward Sensitivity and CVD RiskP01HL040962 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 1988 to 2022
$31.1M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
Neurobiological pathways linking stress and emotion to atherosclerosisR01HL089850 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GIANAROS, PETER J · 2008 to 2016
$4.7M
The Brain as a Target for Pre and Essential HypertensionR01HL101959 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNINGS, JOHN RICHARD · 2010 to 2014
$2.1M
NHLBI NIH HHS P01 HL040962NHLBI NIH HHS P01HL040962NHLBI NIH HHS R01 HL089850NHLBI NIH HHS R01HL089850NHLBI NIH HHS R01 HL101959NHLBI NIH HHS R01HL101959NHLBI NIH HHS T32 HL007560NHLBI NIH HHS T32HL007560
6 · The paper itself

Abstract

We examined the neural correlates of resting cardiac vagal activity in a sample of 432 participants (206 male; 61 African American; mean age 42 years). Pulsed arterial spin labeling was used to quantify whole brain and regional cerebral blood flow at rest. High-frequency heart rate variability (HF-HRV) was used to measure cardiac vagal activity at rest. The primary aim was to determine whether brain regions implicated in regulating cardiac vagal reactions were also related to cardiac vagal activity at rest, and whether these associations varied by sex or race. Brain areas previously related to vagal reactivity were related to resting HF-HRV. Directionality of relationships differed between overall and regional flows. Some relationships were only observed in women and African Americans. There appears to be communality between brain regions associated with task-induced vagal reactivity and those associated with resting cardiac vagal activity.

Indexed as

AdultAutonomic Nervous SystemBrainCerebrovascular CirculationElectrocardiographyFemaleHeart RateHumansMaleMiddle AgedVagus NerveCentral autonomic controlCerebral blood flowHeart rate variabilityRaceSexVagal activity

Identifiers

PMID25174686
PMCPMC4387872
OpenAlexW1493558655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.