Evidence map›Paper›PMID 25174584›Full record

ArticleJournal of medical primatology2015

Massive occlusive thrombosis of the pulmonary artery in pigtailed macaques chronically infected with R5-tropic simian-human immunodeficiency virus.

Cynthia L Courtney, Kelly F Ethun, Francois Villinger, Ruth M Ruprecht, Siddappa N Byrareddy

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of medical primatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cynthia L CourtneyYerkes National Primate Research Center, Emory University, Atlanta, GA, USA; Department of Pathology & Laboratory Medicine, School of Medicine and Emory Vaccine Center, Emory University, Atlanta, GA, USA.
Kelly F Ethun
Francois Villinger
Ruth M Ruprecht
Siddappa N Byrareddy
Emory University · USEmory University Orthopaedics and Spine Hospital · USTexas Biomedical Research Institute · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Infant Immunoprophylaxis against a Primate LentivirusR37AI034266 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI RUPRECHT, RUTH MARGRIT · 2003 to 2012
$7.7M
HIV-1 Env Microglial Tropism and NeurovirulenceR21NS063877 · NINDS · DANA-FARBER CANCER INST · PI RUPRECHT, RUTH MARGRIT · 2008 to 2009
$475k
NIAID NIH HHS R37 AI034266NIH HHS P51 OD011132NIH HHS P51 OD011133NIH HHS P51OD11132NINDS NIH HHS R21 NS063877
6 · The paper itself

Abstract

backgroundPulmonary arterial hypertension (PAH) has been identified as a serious complication of HIV infection. METHODS AND

resultsHere, we report sudden death in two pigtailed macaques (Macaca nemestrina) chronically infected (~1-2 years post-infection) with an R5 SHIV strain. At necropsy, total occlusion of the pulmonary artery by a large fibrin thrombus was present in both animals.

conclusionThis report describes pulmonary vascular lesions similar to PAH in R5 SHIV-infected pigtail macaques.

Indexed as

Animals, LaboratoryMacaca nemestrinaAnimalsFatal OutcomeHypertension, PulmonaryMaleMonkey DiseasesPulmonary ArterySimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusThrombosispulmonary arterial hypertensionSHIVSIV

Identifiers

PMID25174584
PMCPMC4293324
OpenAlexW2045636352

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.