ArticleMolecular medicine reports2014
Increased gastric chromogranin A cell density following changes to diets of patients with irritable bowel syndrome.
Article in Molecular medicine reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Chromogranin A as a Novel Biomarker of Irritable Bowel Syndrome in Adults: A Systematic Review and Meta-Analysis.Middle East journal of digestive diseases · 2025Review
- Gut Microbiota Manipulation in Irritable Bowel Syndrome.Microorganisms · 2022Review
- Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study.Frontiers in medicine · 2022Article
- The role of diet in the pathophysiology and management of irritable bowel syndrome.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Review
- Possible role of intestinal stem cells in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2020Review
- Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones.Nutrients · 2019Review
- Effect of diet and individual dietary guidance on gastrointestinal endocrine cells in patients with irritable bowel syndrome (Review).International journal of molecular medicine · 2017Review
- Dietary fiber in irritable bowel syndrome (Review).International journal of molecular medicine · 2017Article
- Changes in duodenal enteroendocrine cells in patients with irritable bowel syndrome following dietary guidance.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Dietary guidance and ileal enteroendocrine cells in patients with irritable bowel syndrome.Experimental and therapeutic medicine · 2016Article
- Interaction between diet and gastrointestinal endocrine cells.Biomedical reports · 2016Article
- Changes in small intestinal chromogranin A-immunoreactive cell densities in patients with irritable bowel syndrome after receiving dietary guidance.International journal of molecular medicine · 2016Article
- Reduction in duodenal endocrine cells in irritable bowel syndrome is associated with stem cell abnormalities.World journal of gastroenterology · 2015Article
- Recent developments in the pathophysiology of irritable bowel syndrome.World journal of gastroenterology · 2015Review
- Diet in irritable bowel syndrome.Nutrition journal · 2015Review
- Effect of dietary management on the gastric endocrine cells in patients with irritable bowel syndrome.European journal of clinical nutrition · 2015Article
- Increased chromogranin a cell density in the large intestine of patients with irritable bowel syndrome after receiving dietary guidance.Gastroenterology research and practice · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gut endocrine cells control and regulate several functions of the gastrointestinal tract. They have been reported to be abnormal in irritable bowel syndrome (IBS), with alterations occurring in several functions regulated by these cells. Furthermore, it has been established that gut endocrine cells interact with the gut lumen contents, particularly the nutrients. The present study was undertaken to establish whether the positive outcome of dietary guidance observed in patients suffering from IBS is associated with a change in gastric endocrine cells. A total of 46 patients with IBS participated in the present study, of which 14 completed all aspects. These patients included nine females and five males with a mean age of 34 years (range, 20‑45 years). In the healthy control group, nine females and five males, with a mean age of 54 years (range 26‑70 years) were selected. The patients and controls underwent gastroscopy with biopsy samples taken from the corpus and antrum of the stomach. Each patient attended three sessions that lasted ~45 min each, and received individual guidance on their dietary management. The patients followed the diet prescribed for a minimum of three months, then further samples were taken using a method similar to that used for the initial biopsies. The biopsy samples were immunostained using the avidin‑biotin complex method for chromogranin A (CgA) and quantified by computerized image analysis. The patients with IBS presented a low density of CgA compared with the controls. The density of CgA increased in these patients following dietary guidance and changes in food intake. The present observations emphasized the interaction between food intake and gut endocrine cells. The current study also suggests that the positive effects of dietary guidance may be attributed to changes in gut endocrine cell density.
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