ArticleJournal of anxiety disorders2014
Aversive responding to safety signals in panic disorder: the moderating role of intolerance of uncertainty.
Article in Journal of anxiety disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Atypical pupil-linked arousal induced by low-risk probabilistic choices, and intolerance of uncertainty in adults with ASD.Cognitive, affective & behavioral neuroscience · 2025Article
- Investigating the effect of continuous and partial reinforcement in conceptual fear generalization.Scientific reports · 2024Article
- Impact of Intolerance of Uncertainty on Brain Structural Changes in Panic Disorder.Psychiatry investigation · 2023Article
- Intolerance of uncertainty and functional connectivity of the anterior insula during anticipation of unpredictable reward.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023Article
- Using what we know about threat reactivity models to understand mental health during the COVID-19 pandemic.Behaviour research and therapy · 2022Article
- Does cognitive flexibility change the nature of the relationship between intolerance of uncertainty and psychological symptoms during the COVID-19 outbreak in Turkey?Current psychology (New Brunswick, N.J.) · 2022Article
- Neural and Self-report Measures of Sensitivity to Uncertainty as Predictors of COVID-Related Negative Affect.Psychiatry research. Neuroimaging · 2022Article
- Interpersonal trauma exposure and startle reactivity to uncertain threat in individuals with alcohol use disorder.Drug and alcohol dependence · 2020Article
- Modeling anxiety in healthy humans: a key intermediate bridge between basic and clinical sciences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task.Behavioural brain research · 2019Article
- Augmentation of Extinction and Inhibitory Learning in Anxiety and Trauma-Related Disorders.Annual review of clinical psychology · 2019Review
- Commonalities and differences in the neural substrates of threat predictability in panic disorder and specific phobia.NeuroImage. Clinical · 2017Article
- Cognitive flexibility mediates the relation between intolerance of uncertainty and safety signal responding in those with panic disorder.Cognition & emotion · 2016Article
- Intolerance of uncertainty and insula activation during uncertain reward.Cognitive, affective & behavioral neuroscience · 2016Article
- What Is Going On Around Here? Intolerance of Uncertainty Predicts Threat Generalization.PloS one · 2016Article
- Transdiagnostic physiological correlates of unpredictable threat anticipation.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
An inability to inhibit aversive responding during conditions that signal safety may be a core dysfunction associated with anxiety disorders. However, there has been inconsistent evidence as to whether individuals with panic disorder (PD) exhibit aversive responding during safety signals. It is therefore possible that only certain subgroups of PD patients, particularly those with high levels of intolerance of uncertainty (IU), evidence this type of abnormal responding. The aim of the current study was to examine whether IU moderates the association between PD and startle potentiation during (a) safety and (b) threat periods during a threat-of-shock task. Participants included 172 adults, 74 of which had current diagnoses of PD. Results indicated that at high levels of IU, PD was associated with greater startle potentiation during safety. At low levels of IU, PD was not associated with startle potentiation during safety. IU did not moderate the effect of PD on threat responding. These results suggest that PD patients with high levels of IU fail to inhibit aversive responding during safety, possibly due to a tendency to interpret distal threat as distressing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.