ArticleGenetics2014
Exploiting natural variation of secondary metabolism identifies a gene controlling the glycosylation diversity of dihydroxybenzoic acids in Arabidopsis thaliana.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
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- Enhanced bioproduction of phenolic compounds fromFrontiers in molecular biosciences · 2025Article
- Altering cold-regulated gene expression decouples the salicylic acid-growth trade-off in Arabidopsis.The Plant cell · 2024Article
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- 2,4-Dihydroxybenzoic Acid, a Novel SA Derivative, Controls Plant Immunity via UGT95B17-Mediated Glucosylation: A Case Study in Camellia Sinensis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- QT-GWAS: A novel method for unveiling biosynthetic loci affecting qualitative metabolic traits.Molecular plant · 2023Article
- SlS5H silencing reveals specific pathogen-triggered salicylic acid metabolism in tomato.BMC plant biology · 2022Article
- Salicylic Acid Is Required for Broad-Spectrum Disease Resistance in Rice.International journal of molecular sciences · 2022Article
- Metabolic source isotopic pair labeling and genome-wide association are complementary tools for the identification of metabolite-gene associations in plants.The Plant cell · 2021Article
- Identifying genetic variants underlying phenotypic variation in plants without complete genomes.Nature genetics · 2020Article
- Tomato glycosyltransferase Twi1 plays a role in flavonoid glycosylation and defence against virus.BMC plant biology · 2019Article
- A genetical metabolomics approach for bioprospecting plant biosynthetic gene clusters.BMC research notes · 2019Article
- Discovering variation of secondary metabolite diversity and its relationship with disease resistance inEcology and evolution · 2018Article
- Modulation of Plant Salicylic Acid-Associated Immune Responses via Glycosylation of Dihydroxybenzoic Acids.Plant physiology · 2018Article
- Article
- Integrated omics analyses of retrograde signaling mutant delineate interrelated stress-response strata.The Plant journal : for cell and molecular biology · 2017Article
- Genetic dissection of metabolite variation in Arabidopsis seeds: evidence for mQTL hotspots and a master regulatory locus of seed metabolism.Journal of experimental botany · 2017Article
- Natural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data.Scientific reports · 2016Article
- Discovery of a novel amino acid racemase through exploration of natural variation in Arabidopsis thaliana.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant secondary metabolism is an active research area because of the unique and important roles the specialized metabolites have in the interaction of plants with their biotic and abiotic environment, the diversity and complexity of the compounds and their importance to human medicine. Thousands of natural accessions of Arabidopsis thaliana characterized with increasing genomic precision are available, providing new opportunities to explore the biochemical and genetic mechanisms affecting variation in secondary metabolism within this model species. In this study, we focused on four aromatic metabolites that were differentially accumulated among 96 Arabidopsis natural accessions as revealed by leaf metabolic profiling. Using UV, mass spectrometry, and NMR data, we identified these four compounds as different dihydroxybenzoic acid (DHBA) glycosides, namely 2,5-dihydroxybenzoic acid (gentisic acid) 5-O-β-D-glucoside, 2,3-dihydroxybenzoic acid 3-O-β-D-glucoside, 2,5-dihydroxybenzoic acid 5-O-β-D-xyloside, and 2,3-dihydroxybenzoic acid 3-O-β-D-xyloside. Quantitative trait locus (QTL) mapping using recombinant inbred lines generated from C24 and Col-0 revealed a major-effect QTL controlling the relative proportion of xylosides vs. glucosides. Association mapping identified markers linked to a gene encoding a UDP glycosyltransferase gene. Analysis of Transfer DNA (T-DNA) knockout lines verified that this gene is required for DHBA xylosylation in planta and recombinant protein was able to xylosylate DHBA in vitro. This study demonstrates that exploiting natural variation of secondary metabolism is a powerful approach for gene function discovery.
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