ArticleNature nanotechnology2014
Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform.
Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed.
- Massively Multiplexed Photonic Chip With Cross-Channel Fusion For Harmonized Biosensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Single-Nanoparticle Detection Using Quasi-Bound States in the Continuum Supported by Silicon Metasurfaces.Small methods · 2026Article
- Molecule by Molecule Characterization of a Polymer Molecular Mass Distribution via Mass Photometry.Angewandte Chemie (International ed. in English) · 2026Article
- Label-Free Optical Differentiation of Single Diffusing Amino Acids at Picomolar Concentrations.Research square · 2026Article
- Nanometer-Precision Tracking of Adipocyte Dynamics via Single Lipid Droplet Whispering-Gallery Optical Resonances.ACS sensors · 2026Article
- Design of Functionalized Photon Sieves for the Detection of Biomarkers in Running Fluids.Sensors (Basel, Switzerland) · 2026Article
- Single-Particle Photothermal Microscopy Using On-Chip Silicon Nitride Microring Resonators.The journal of physical chemistry. A · 2026Article
- Single-atomic-ion detection with plasmon-enhanced whispering-gallery-mode microlasers.Nature photonics · 2026Article
- Emerging frontiers in SERS-integrated optical waveguides: advancing portable and ultra-sensitive detection for trace liquid analysis.Light, science & applications · 2025Review
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- Monitoring Single DNA Docking Site Activity with Sequential Modes of an Optoplasmonic Whispering-Gallery Mode Biosensor.Sensors (Basel, Switzerland) · 2025Article
- FLOWER: a frequency-locked optical whispering evanescent resonator for label-free molecular detection.Chemical communications (Cambridge, England) · 2025Review
- Fabrication, Characterization, and Sensor Applications of Polymer-Based Whispering Gallery Mode Microresonators.ACS sensors · 2025Review
- Single-molecule manipulation and detection by WGM-coupled photonic nanojets.Discover nano · 2025Article
- Highly sensitive microdisk laser sensor for refractive index sensing via periodic meta-hole patterning.Nanophotonics (Berlin, Germany) · 2025Article
- DNA Sensing with Whispering Gallery Mode Microlasers.Nano letters · 2025Article
- Label-free (fluorescence-free) sensing of a single DNA molecule on DNA origami using a plasmon-enhanced WGM sensor.Nanophotonics (Berlin, Germany) · 2025Article
- Optical biosensors for diagnosing neurodegenerative diseases.Npj biosensing · 2025Review
- Surpassing the Diffraction Limit in Label-Free Optical Microscopy.ACS photonics · 2024Review
64 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosensing relies on the detection of molecules and their specific interactions. It is therefore highly desirable to develop transducers exhibiting ultimate detection limits. Microcavities are an exemplary candidate technology for demonstrating such a capability in the optical domain and in a label-free fashion. Additional sensitivity gains, achievable by exploiting plasmon resonances, promise biosensing down to the single-molecule level. Here, we introduce a biosensing platform using optical microcavity-based sensors that exhibits single-molecule sensitivity and is selective to specific single binding events. Whispering gallery modes in glass microspheres are used to leverage plasmonic enhancements in gold nanorods for the specific detection of nucleic acid hybridization, down to single 8-mer oligonucleotides. Detection of single intercalating small molecules confirms the observation of single-molecule hybridization. Matched and mismatched strands are discriminated by their interaction kinetics. Our platform allows us to monitor specific molecular interactions transiently, hence mitigating the need for high binding affinity and avoiding permanent binding of target molecules to the receptors. Sensor lifetime is therefore increased, allowing interaction kinetics to be statistically analysed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.