Evidence map›Paper›PMID 25173540›Full record

ArticleAmerican heart journal2014

Parathyroid hormone concentration and risk of cardiovascular diseases: the Atherosclerosis Risk in Communities (ARIC) study.

Aaron R Folsom, Alvaro Alonso, Jeffrey R Misialek, Erin D Michos, Elizabeth Selvin, John H Eckfeldt, Josef Coresh, James S Pankow, Pamela L Lutsey

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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  20. Physical Activity and Lifetime Risk of Cardiovascular Disease and Cancer.Medicine and science in sports and exercise · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aaron R FolsomDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN. Electronic address: folso001@umn.edu.
Alvaro AlonsoDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Jeffrey R MisialekDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Erin D MichosDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD.
Elizabeth SelvinDivision of General Internal Medicine, Department of Medicine, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, MD; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
John H EckfeldtLaboratory Medicine & Pathology, University of Minnesota, Minneapolis, MN.
Josef CoreshDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD.
James S PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
Pamela L LutseyDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN.
University of Minnesota · USJohns Hopkins University · US

Funding

Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC CohortR01HL103706 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2011 to 2014
$2.3M
Vitamin D, cerebrovascular risk, and neurocognitive decline: ARIC Brain MRI StudyR01NS072243 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MICHOS, ERIN D · 2011 to 2014
$1.4M
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL103706NIDDK NIH HHS R01 DK089174NINDS NIH HHS R01 NS072243
6 · The paper itself

Abstract

backgroundAccording to a recent meta-analysis, parathyroid hormone (PTH) excess is associated with increased cardiovascular disease (CVD) risk, but existing studies are limited. We examined in a prospective study the association of PTH with the incidence of CVD, taking into account vitamin D and other confounding variables.

methodsThe ARIC study measured PTH using a second-generation assay (Roche, Indianapolis, IN) in stored serum samples from 1990 to 1992 and related levels in 10,392 adults to incident cardiovascular outcomes (coronary heart disease [n = 808], heart failure [n = 1,294], stroke [n = 586], peripheral artery disease [n = 873], atrial fibrillation [n = 1,190], and CVD mortality [n = 647]) through 2010 (median follow-up 19 years).

resultsContrary to the hypothesis, PTH level was not associated positively with any CVD outcome. The associations of incident heart failure, peripheral artery disease, and CVD mortality with PTH actually were weakly inverse (P trend = .02-.04) in the most fully adjusted models. For example, the hazard ratios across PTH quartiles were 1.00, 1.07, 1.07, and 0.96 (P trend = .74) for coronary heart disease incidence and were 1.00, 0.69, 0.74, and 0.74 (P trend = .02) for CVD mortality. Patterns were similar when restricted to participants with normal baseline kidney function.

conclusionsThis large prospective study failed to support the hypothesis that elevated PTH is an independent risk marker for incident CVD. When our data were added to the previous meta-analysis, the pooled hazard ratio remained statistically significant but weakened.

Indexed as

Cardiovascular DiseasesFemaleHumansIncidenceMaleMiddle AgedParathyroid HormoneProspective StudiesRisk AssessmentParathyroid Hormone

Identifiers

PMID25173540
PMCPMC4150218
OpenAlexW1975381761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.