ArticleNature structural & molecular biology2014
High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast.
Article in Nature structural & molecular biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 77 citations in OpenAlex.
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- Metabolite accumulation mediates the shift between the High Oxygen Consumption and Low Oxygen Consumption phases in the Yeast Metabolic Cycle.bioRxiv : the preprint server for biology · 2025Article
- Temporal oscillation of phospholipids promotes metabolic efficiency.Nature chemical biology · 2025Article
- A four eigen-phase model of multi-omics unveils new insights into yeast metabolic cycle.NAR genomics and bioinformatics · 2025Article
- Dynamic metabolic regulation of histone modifications during the yeast metabolic cycle.PloS one · 2025Article
- Design of Four Small-Molecule-Inducible Systems in the Yeast Chromosome, Applied to Optimize Terpene Biosynthesis.ACS synthetic biology · 2023Article
- Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle.Nature metabolism · 2023Article
- A microbiota-epigenetic circuit controls systematic circadian programs in the gut epithelium.Frontiers in systems biology · 2023Article
- Shade triggers posttranscriptional PHYTOCHROME-INTERACTING FACTOR-dependent increases in H3K4 trimethylation.Plant physiology · 2022Article
- Distinct functions of three chromatin remodelers in activator binding and preinitiation complex assembly.PLoS genetics · 2022Article
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- Cancer cell metabolism connects epigenetic modifications to transcriptional regulation.The FEBS journal · 2022Review
- Glucose starvation induces a switch in the histone acetylome for activation of gluconeogenic and fat metabolism genes.Molecular cell · 2022Article
- Investigating crosstalk between H3K27 acetylation and H3K4 trimethylation in CRISPR/dCas-based epigenome editing and gene activation.Scientific reports · 2021Article
- Chromatin-remodeling links metabolic signaling to gene expression.Molecular metabolism · 2020Review
- Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.Genome research · 2020Article
- Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.Molecular cell · 2019Article
- The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3.Science (New York, N.Y.) · 2019Article
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Under continuous, glucose-limited conditions, budding yeast exhibit robust metabolic cycles associated with major oscillations of gene expression. How such fluctuations are linked to changes in chromatin status is not well understood. Here we examine the correlated genome-wide transcription and chromatin states across the yeast metabolic cycle at unprecedented temporal resolution, revealing a 'just-in-time supply chain' by which components from specific cellular processes such as ribosome biogenesis become available in a highly coordinated manner. We identify distinct chromatin and splicing patterns associated with different gene categories and determine the relative timing of chromatin modifications relative to maximal transcription. There is unexpected variation in the chromatin modification and expression relationship, with histone acetylation peaks occurring with varying timing and 'sharpness' relative to RNA expression both within and between cycle phases. Chromatin-modifier occupancy reveals subtly distinct spatial and temporal patterns compared to those of the modifications themselves.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.