Evidence map›Paper›PMID 25173134›Full record

ArticleThe American journal of pathology2014

Impaired bone resorption and woven bone formation are associated with development of osteonecrosis of the jaw-like lesions by bisphosphonate and anti-receptor activator of NF-κB ligand antibody in mice.

Drake W Williams, Cindy Lee, Terresa Kim, Hideo Yagita, Hongkun Wu, Sil Park, Paul Yang, Honghu Liu, Songtao Shi, Ki-Hyuk Shin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Mesenchymal Stem Cells in Socket Healing and MRONJ.Orthodontics & craniofacial research · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Risk comparison of osteonecrosis of the jaw in osteoporotic patients treated with bisphosphonates vs. denosumab: a multi-institutional retrospective cohort study in Taiwan.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Drake W WilliamsSchool of Dentistry, University of California at Los Angeles, Los Angeles, California.
Cindy LeeSchool of Dentistry, University of California at Los Angeles, Los Angeles, California.
Terresa KimSchool of Dentistry, University of California at Los Angeles, Los Angeles, California.
Hideo YagitaDepartment of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Hongkun WuState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Sil ParkSchool of Dentistry, University of California at Los Angeles, Los Angeles, California.
Paul YangSchool of Dentistry, University of California at Los Angeles, Los Angeles, California.
Honghu LiuSchool of Dentistry, University of California at Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; Fielding School of Public Health, University of California at Los Angeles, Los Angeles, California.
Songtao ShiCenter for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California.
Ki-Hyuk ShinSchool of Dentistry, University of California at Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.
Mo K KangSchool of Dentistry, University of California at Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.
No-Hee ParkSchool of Dentistry, University of California at Los Angeles, Los Angeles, California; David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California; Kyung Hee University, Seoul, Korea.
Reuben H KimSchool of Dentistry, University of California at Los Angeles, Los Angeles, California; Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California. Electronic address: rkim@dentistry.ucla.edu.

Funding

Molecular mechanisms of drug-induced ONJ and osteomucosal chronic woundsR01DE023348 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIM, REUBEN HAN-KYU · 2013 to 2017
$1.9M
Role of oral mucosa in bisphosphonate related osteonecrosis of the jawR03DE021114 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIM, REUBEN HAN-KYU · 2010 to 2011
$231k
NIDCR NIH HHS R01 DE023348NIDCR NIH HHS R01DE023348NIDCR NIH HHS R03 DE021114NIDCR NIH HHS R03DE021114
6 · The paper itself

Abstract

Drug-induced osteonecrosis of the jaw (ONJ) is a detrimental intraoral lesion that often occurs after dental-related interventions in patients undergoing treatment with bisphosphonates or denosumab, the neutralizing human anti-receptor activator of NF-κB ligand (RANKL) antibody (Ab). The cause of ONJ by these drugs has been speculated to their direct effects on osteoclasts. However, the extent to which osteoclasts contribute to ONJ pathogenesis remains controversial. Herein, by using a tooth-extraction mouse model with i.v. administration of mouse anti-RANKL Ab or the bisphosphonate zoledronate (ZOL), we show that unresorbed bone due to impaired formation or suppressed functions of osteoclasts, respectively, is associated with ONJ development. After tooth extraction, ONJ-like lesions developed 50% in the anti-RANKL Ab-treated mice and 30% in the ZOL-treated mice. Nonviable and unresorbed bone was found more in anti-RANKL Ab-treated mice compared with mice receiving ZOL. All mice receiving anti-RANKL Ab had an undetectable tartrate-resistant acid phosphatase (TRAP) level in the serum and no TRAP-positive osteoclasts at the extracted sockets, whereas ZOL-treated mice had a decreased TRAP level without altering the numbers of TRAP-positive osteoclasts. Interestingly, the absence of newly formed woven bone in the extracted sockets was evident in ONJ-like lesions from both anti-RANKL Ab- and ZOL-treated mice. Our study suggests that the lack of osteoclasts' bone-resorptive functions by these drugs and suppression of woven bone formation after dental trauma may be associated with ONJ development.

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedBisphosphonate-Associated Osteonecrosis of the JawBone ResorptionDenosumabDiphosphonatesDisease Models, AnimalImidazolesMiceOsteoclastsRANK LigandZoledronic AcidAntibodies, Monoclonal, HumanizedDenosumabDiphosphonatesImidazolesRANK LigandZoledronic Acid

Identifiers

PMID25173134
PMCPMC4215026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.