ArticleThe Journal of chemical physics2014
Communication: Charge, diffusion, and mobility of proteins through nanopores.
Article in The Journal of chemical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Supramolecular framework membrane for precise sieving of small molecules, nanoparticles and proteins.Nature communications · 2023Article
- Structure and Dynamics of dsDNA in Cell-like Environments.Entropy (Basel, Switzerland) · 2022Review
- Threading single proteins through pores to compare their energy landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Channels with Helical Modulation Display Stereospecific Sensitivity for Chiral Superstructures.Polymers · 2021Article
- Theory of ionic conductivity with morphological control in polymers.ACS macro letters · 2021Article
- Article
- Beyond mass spectrometry, the next step in proteomics.Science advances · 2020Review
- Engineering and Modeling the Electrophoretic Trapping of a Single Protein Inside a Nanopore.ACS nano · 2019Article
- Simulation of single-protein nanopore sensing shows feasibility for whole-proteome identification.PLoS computational biology · 2019Article
- Theoretical Modeling of Polymer Translocation: From the Electrohydrodynamics of Short Polymers to the Fluctuating Long Polymers.Polymers · 2019Review
- Single-molecule protein sensing in a nanopore: a tutorial.Chemical Society reviews · 2018Review
- Sensing Native Protein Solution Structures Using a Solid-state Nanopore: Unraveling the States of VEGF.Scientific reports · 2018Article
- Single-molecule nanopore enzymology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Stochastic resonance during a polymer translocation process.The Journal of chemical physics · 2016Article
- Temperature Effect on Ionic Current and ssDNA Transport through Nanopores.Biophysical journal · 2015Article
- Dynamics and Energy Contributions for Transport of Unfolded Pertactin through a Protein Nanopore.ACS nano · 2015Article
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1 author.
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Abstract
Implementation of Einstein's law connecting charge, diffusion coefficient, and mobility to interpret experimental data on proteins from single molecule electrophoresis through nanopores faces serious difficulties. The protein charge and diffusion coefficient, inferred with the Einstein law, can be orders of magnitude smaller than their bare values depending on the electrolyte concentration, pore diameter, chemical nature of the pore wall, and the externally applied voltage. The main contributors to the discrepancies are the coupled dynamics of the protein and its counterion cloud, confinement effects inside the pore, and the protein-pore-surface interaction. We have addressed these ingredients by harking on classical theories of electrophoresis of macroions and hydrodynamics inside pores, and deriving new results for pore-protein interactions. Putting together various components, we present approximate analytical formulas for the effective charge, diffusion coefficient, and mobility of a protein in the context of single molecule electrophoresis experiments. For the omnipresent pore-protein interactions, nonlinear dependence of the velocity of protein on voltage sets in readily and analytical formulas for this effect are presented. The derived formulas enable the determination of the bare charge and size of a protein from the experimentally measured apparent values.
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