ArticleProceedings of the National Academy of Sciences of the United States of America2014
Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
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- Amplitude and frequency encoding result in qualitatively distinct informational landscapes in cell signaling.Scientific reports · 2025Article
- Information bounds on the accuracy of cell polarization.PloS one · 2025Article
- The GravyTrain toolbox for molecular cell biology.PloS one · 2025Article
- Transient frequency preference responses in cell signaling systems.NPJ systems biology and applications · 2024Article
- Single-cell directional sensing from just a few receptor binding events.Biophysical journal · 2023Article
- Modulation of transcription factor dynamics allows versatile information transmission.Scientific reports · 2023Article
- Frequency-preference response in covalent modification cycles under substrate sequestration conditions.NPJ systems biology and applications · 2021Article
- Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves.PLoS computational biology · 2020Article
- Mitotic and pheromone-specific intrinsic polarization cues interfere with gradient sensing inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Ratiometric GPCR signaling enables directional sensing in yeast.PLoS biology · 2019Article
- Intrinsic limits of information transmission in biochemical signalling motifs.Interface focus · 2018Article
- Cluster Analysis of Endogenous HER2 and HER3 Receptors in SKBR3 Cells.Bio-protocol · 2018Article
- Properties of cell signaling pathways and gene expression systems operating far from steady-state.Scientific reports · 2018Article
- Parameter uncertainty quantification using surrogate models applied to a spatial model of yeast mating polarization.PLoS computational biology · 2018Article
- Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling.Molecular systems biology · 2018Article
- Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction.PLoS computational biology · 2018Article
- Oscillatory IL-2 stimulus reveals pertinent signaling timescales of T cell responsiveness.PloS one · 2018Article
- Testing the limits of gradient sensing.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells use to take advantage of the information present in the early signal, before receptor binding reaches a new steady state. This mechanism, pre-equilibrium sensing and signaling (PRESS), operates in signaling systems in which the kinetics of ligand-receptor binding are slower than the downstream signaling steps, and it typically involves transient activation of a downstream step. In the systems where it operates, PRESS expands and shifts the input dynamic range, allowing cells to make different responses to ligand concentrations so high as to be otherwise indistinguishable. Specifically, we show that PRESS applies to the yeast directional polarization in response to pheromone gradients. Consideration of preexisting kinetic data for ligand-receptor interactions suggests that PRESS operates in many cell signaling systems throughout biology. The same mechanism may also operate at other levels in signaling systems in which a slow activation step couples to a faster downstream step.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.