ArticleJournal of immunology (Baltimore, Md. : 1950)2014
CD4+ T cells and CD40 participate in selection and homeostasis of peripheral B cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 29 citations in OpenAlex.
- Investigation of the mechanism of hypertension caused by BTKi in the treatment of hematologic diseases.Frontiers in pharmacology · 2025Review
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- B-cell maturation antigen targeting strategies in multiple myeloma treatment, advantages and disadvantages.Journal of translational medicine · 2022Review
- Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.Leukemia · 2022Article
- AID in Chronic Lymphocytic Leukemia: Induction and Action During Disease Progression.Frontiers in oncology · 2021Review
- Targeting Bruton's Tyrosine Kinase in Inflammatory and Autoimmune Pathologies.Frontiers in cell and developmental biology · 2021Review
- Homeostasis and regulation of autoreactive B cells.Cellular & molecular immunology · 2020Review
- The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Sex Differences in Older Adults' Immune Responses to Seasonal Influenza Vaccination.Frontiers in immunology · 2019Article
- Activated PIK3CD drives innate B cell expansion yet limits B cell-intrinsic immune responses.The Journal of experimental medicine · 2018Article
- αv Integrins regulate germinal center B cell responses through noncanonical autophagy.The Journal of clinical investigation · 2018Article
- The Autoimmune Risk VariantJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Comparative Evaluation of αCD40 (2C10R4) and αCD154 (5C8H1 and IDEC-131) in a Nonhuman Primate Cardiac Allotransplant Model.Transplantation · 2017Article
- Altered B cell signalling in autoimmunity.Nature reviews. Immunology · 2017Review
- Role of Sex Hormone Levels and Psychological Stress in the Pathogenesis of Autoimmune Diseases.Cureus · 2017Review
- Mediation of transitional B cell maturation in the absence of functional Bruton's tyrosine kinase.Scientific reports · 2017Article
- Somatically Hypermutated Plasmodium-Specific IgM(+) Memory B Cells Are Rapid, Plastic, Early Responders upon Malaria Rechallenge.Immunity · 2016Article
- Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells.Current opinion in immunology · 2015Review
- Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.The Journal of experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Control of peripheral B cell development and homeostasis depends critically on coordinate signals received through the BAFFRs and BCRs. The extent to which other signals contribute to this process, however, remains undefined. We present data indicating that CD4(+) T cells directly influence naive B cell development via CD40 signaling. Loss of CD4(+) T cells or CD40-CD40L interaction leads to reduced B cell homeostatic proliferation and hindered B cell reconstitution posttransplantation. Furthermore, we demonstrate that in the absence of CD40 signals, these events are modulated by BCR self-reactivity. Strikingly, murine models lacking CD40 reveal a broadly altered BCR specificity and limited diversity by both single-cell cloning and high-throughput sequencing techniques. Collectively, our results imply that any setting of T cell lymphopenia or reduced CD40 function, including B cell recovery following transplantation, will impact the naive B cell repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.