ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses.The Journal of experimental medicine · 2026Article
- Calibrating T cell responsiveness through interactions with self.Nature reviews. Immunology · 2026Review
- Single-cell gene expression and TCR profiling reveal age-related differences in recent thymic emigrants.iScience · 2026Article
- An early burst of cytokine production before the first cell division influences CD8 T cell differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Measuring thymic output across the human lifespan: a critical challenge in laboratory medicine.GeroScience · 2025Review
- Functional heterogeneity and plasticity in naïve CD8 T cells drive superior effector and memory responses.bioRxiv : the preprint server for biology · 2025Article
- Early-life human CD8Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Recent thymic emigrants preferentially undergo memory inflation after persistent infection.PLoS pathogens · 2025Article
- T cell egress via lymphatic vessels is tuned by antigen encounter and limits tumor control.Nature immunology · 2023Article
- Early age-related atrophy of cutaneous lymph nodes precipitates an early functional decline in skin immunity in mice with aging.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Testosterone Protects Against Atherosclerosis in Male Mice by Targeting Thymic Epithelial Cells-Brief Report.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- Reinterpreting recent thymic emigrant function: defective or adaptive?Current opinion in immunology · 2018Review
- Cutting Edge: Defective Aerobic Glycolysis Defines the Distinct Effector Function in Antigen-Activated CD8Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Stochastic descriptors to study the fate and potential of naive T cell clonotypes in the periphery.Journal of mathematical biology · 2017Article
- Recent thymic emigrants are tolerized in the absence of inflammation.The Journal of experimental medicine · 2016Article
- Cutting Edge: Enhanced Clonal Burst Size Corrects an Otherwise Defective Memory Response by CD8+ Recent Thymic Emigrants.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- On Peptides and Altered Peptide Ligands: From Origin, Mode of Action and Design to Clinical Application (Immunotherapy).International archives of allergy and immunology · 2016Review
- T Cell Adolescence: Maturation Events Beyond Positive Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Review
- Cutting Edge: Caspase-11 Limits the Response of CD8+ T Cells to Low-Abundance and Low-Affinity Antigens.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
To explore the TCR sensitivity of recent thymic emigrants (RTEs), we triggered T cells with altered peptide ligands (APLs). Upon peptide stimulation in vitro, RTEs exhibited increased TCR signal transduction, and following infection in vivo with APL-expressing bacteria, CD8 RTEs expanded to a greater extent in response to low-affinity Ags than did their mature T cell counterparts. RTEs skewed to short-lived effector cells in response to all APLs but also were characterized by diminished cytokine production. RTEs responding to infection expressed increased levels of VLA-4, with consequent improved entry into inflamed tissue and pathogen clearance. These positive outcomes were offset by the capacity of RTEs to elicit autoimmunity. Overall, salient features of CD8 RTE biology should inform strategies to improve neonatal vaccination and therapies for cancer and HIV, because RTEs make up a large proportion of the T cells in lymphodepleted environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.