ReviewVirchows Archiv : an international journal of pathology2014
Recent advances in the diagnostic pathology of salivary carcinomas.
Review in Virchows Archiv : an international journal of pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Evolving Concepts in Salivary Duct Carcinoma: A Narrative Review.Oncology and therapy · 2026Review
- Salivary Duct Carcinoma: A Case Report With Cytological and Immunohistochemical Study and Review of Literature.Cureus · 2025Article
- Targeted molecular profiling of salivary duct carcinoma with rhabdoid features highlights parallels to other apocrine and discohesive neoplasms: which phenotype should drive classification?Head and neck pathology · 2022Article
- Development of head and neck pathology in Europe.Virchows Archiv : an international journal of pathology · 2022Review
- Beyond Surgical Treatment in Adenoid Cystic Carcinoma of the Head and Neck: A Literature Review.Cancer management and research · 2022Review
- Metastatic renal cell carcinoma to the oral cavity as first sign of disease: A case report.Clinical case reports · 2020Article
- [Expression of thymidylate synthase in salivary adenoid myoepithelial cells and its clinical significance].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers.Head and neck pathology · 2019Article
- Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available.Case reports in pathology · 2019Article
- UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.Oral oncology · 2018Article
- Metastatic Salivary Ductal Carcinoma to the Mastoid Segment of the Facial Nerve.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
- Mammary analogue secretory carcinoma of salivary glands: diagnostic pitfall with distinct immunohistochemical profile and molecular features.Rare tumors · 2017Article
- Secretory carcinoma - impact of translocation and gene fusions on salivary gland tumor.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2017Article
- Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature.Frontiers in medicine · 2017Article
- Expression, Mutation, and Amplification Status of EGFR and Its Correlation with Five miRNAs in Salivary Gland Tumours.BioMed research international · 2017Article
- Newly described salivary gland tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Review
- Lysozyme Expression Can be Useful to Distinguish Mammary Analog Secretory Carcinoma from Acinic Cell Carcinoma of Salivary Glands.Head and neck pathology · 2016Article
- Salivary acinic cell carcinoma: reappraisal and update.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Review
- Fusion proteins in head and neck neoplasms: Clinical implications, genetics, and future directions for targeting.Cancer biology & therapy · 2016Article
- Targeting MDM2 for Treatment of Adenoid Cystic Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review concentrates on the most important developments since the WHO classification of 2005. In particular, the identification of specific translocations is revolutionising the way salivary tumours are considered and will have a major impact on future diagnostic practice. This is true so far in four malignancies: mammary analogue secretory, mucoepidermoid, adenoid cystic and hyalinising clear cell carcinomas. In each, the gene rearrangement is found in 80 % or more of cases. Two 2014 publications have added further possible candidates with molecular abnormalities to the list (cribriform adenocarcinoma of the tongue and minor salivary glands and epithelial-myoepithelial carcinoma), but these findings have yet to be confirmed by other investigators. The advances in molecular pathology have also allowed re-evaluation of the morphology; for example, it is now realised that the histological spectrum of hyalinising clear cell carcinoma includes intracellular mucin in over half of cases, as well as tumours with only scanty clear cells. In a separate development, it is now proposed that salivary duct carcinoma can be subdivided along molecular lines, in ways analogous to breast cancer, suggesting new therapeutic prospects in an otherwise highly aggressive malignancy.
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