ArticleToxicology2014
Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.
Article in Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Lung inflammation after repeated exposure to LPS and glyphosate in female mice.Scientific reports · 2026Article
- From Invisibility to Inclusion: Evidence, Lived Experience, and Policy Directions for Multiple Chemical Sensitivity Report from the Resilience 2025 International Conference.International journal of environmental research and public health · 2026Article
- Immunomodulatory effects of the herbicide glyphosate following occupational exposure.Archives of toxicology · 2025Article
- Combined glyphosate and chlorpyrifos-based pesticides impair innate and adaptive immune functions: an in vitro approach.Environmental health : a global access science source · 2025Article
- Associations Between Urinary Pesticide Metabolites and Serum Inflammatory Biomarkers in Adolescents Living in an Agricultural Region.Exposure and health · 2025Article
- Importance of mast cell histamine secretion in IgG-mediated systemic anaphylaxis.The Journal of allergy and clinical immunology · 2025Article
- Associations between urinary glyphosate and arthritis: an US NHANES analysis.Frontiers in public health · 2025Article
- Characterization of pesticide exposures and their associations with asthma morbidity in a predominantly low-income urban pediatric cohort in Baltimore City.Environmental research · 2024Article
- Exposure to agricultural pesticides and wheezing among 5-12-year-old children in the Imperial Valley, CA, USA.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication.ACS pharmacology & translational science · 2024Review
- Pesticide use patterns and their association with cytokine levels in Mexican flower workers.International archives of occupational and environmental health · 2024Article
- Mast Cells in Autism Spectrum Disorder-The Enigma to Be Solved?International journal of molecular sciences · 2024Review
- Overview of human health effects related to glyphosate exposure.Frontiers in toxicology · 2024Review
- Pesticide-Induced Inflammation at a Glance.Toxics · 2023Review
- Adhesion Molecules in Lung Inflammation from Repeated Glyphosate Exposures.International journal of environmental research and public health · 2023Article
- Exposure to glyphosate in the United States: Data from the 2013-2014 National Health and Nutrition Examination Survey.Environment international · 2022Article
- Effects of exposure to glyphosate on oxidative stress, inflammation, and lung function in maize farmers, Northern Thailand.BMC public health · 2022Article
- Suspected gut barrier disruptors and development of food allergy: Adjuvant effects and early immune responses.Frontiers in allergy · 2022Article
- Direct Effects of Glyphosate onFrontiers in immunology · 2022Article
- Pleiotropic Outcomes of Glyphosate Exposure: From Organ Damage to Effects on Inflammation, Cancer, Reproduction and Development.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Several low weight molecules have often been implicated in the induction of occupational asthma. Glyphosate, a small molecule herbicide, is widely used in the world. There is a controversy regarding a role of glyphosate in developing asthma and rhinitis among farmers, the mechanism of which is unexplored. The aim of this study was to explore the mechanisms of glyphosate induced pulmonary pathology by utilizing murine models and real environmental samples. C57BL/6, TLR4-/-, and IL-13-/- mice inhaled extracts of glyphosate-rich air samples collected on farms during spraying of herbicides or inhaled different doses of glyphosate and ovalbumin. The cellular response, humoral response, and lung function of exposed mice were evaluated. Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5. In contrast, in vivo systemic IL-4 production was not increased. Co-administration of ovalbumin with glyphosate did not substantially change the inflammatory immune response. However, IL-13-deficiency resulted in diminished inflammatory response but did not have a significant effect on airway resistance upon methacholine challenge after 7 or 21 days of glyphosate exposure. Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone. This study, for the first time, provides evidence for the mechanism of glyphosate-induced occupational lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.