ArticleThe Plant cell2014
Manipulation of mitogen-activated protein kinase kinase signaling in the Arabidopsis stomatal lineage reveals motifs that contribute to protein localization and signaling specificity.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Clathrin-mediated endocytosis of ERECTA family receptors is essential for proper stomatal development inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phospho-Proteomics Identifies D-Group MAP Kinases as Substrates of thePlant direct · 2026Article
- Phosphorylation-dependent activation of the bHLH transcription factor ICE1/SCRM promotes polarization of the Arabidopsis zygote.The New phytologist · 2025Article
- Century-long timelines of herbarium genomes predict plant stomatal response to climate change.Nature ecology & evolution · 2024Article
- Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis.Current biology : CB · 2024Article
- Specificity models in MAPK cascade signaling.FEBS open bio · 2023Review
- The functional specificity of ERECTA-family receptors in Arabidopsis stomatal development is ensured by molecular chaperones in the endoplasmic reticulum.Development (Cambridge, England) · 2022Article
- Mitogen-Activated Protein Kinase and Substrate Identification in Plant Growth and Development.International journal of molecular sciences · 2022Review
- Spatiotemporal control of miR398 biogenesis, via chromatin remodeling and kinase signaling, ensures proper ovule development.The Plant cell · 2021Article
- SPEECHLESS and MUTE Mediate Feedback Regulation of Signal Transduction during Stomatal Development.Plants (Basel, Switzerland) · 2021Review
- The MAPK substrate MASS proteins regulate stomatal development in Arabidopsis.PLoS genetics · 2020Article
- Stomatal Development and Perspectives toward Agricultural Improvement.Cold Spring Harbor perspectives in biology · 2019Review
- Mitogen-activated protein kinases MPK3 and MPK6 are required for stem cell maintenance in the Arabidopsis shoot apical meristem.Plant cell reports · 2019Article
- EPFL Signals in the Boundary Region of the SAM Restrict Its Size and Promote Leaf Initiation.Plant physiology · 2019Article
- Dissection of MAPK signaling specificity through protein engineering in a developmental context.BMC plant biology · 2018Article
- Molecular control of stomatal development.The Biochemical journal · 2018Review
- Genome-wide identification and analysis of MAPK and MAPKK gene family in Chinese jujube (Ziziphus jujuba Mill.).BMC genomics · 2017Article
- Integration analysis of MKK and MAPK family members highlights potential MAPK signaling modules in cotton.Scientific reports · 2016Article
- Mitogen-Activated Protein Kinase Kinase 3 Is Required for Regulation during Dark-Light Transition.Molecules and cells · 2015Article
Corrections and comments
- Erratum issuedCorrection.2015
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When multiple mitogen-activated protein kinase (MAPK) components are recruited recurrently to transduce signals of different origins, and often opposing outcomes, mechanisms to enforce signaling specificity are of utmost importance. These mechanisms are largely uncharacterized in plant MAPK signaling networks. The Arabidopsis thaliana stomatal lineage was previously used to show that when rendered constitutively active, four MAPK kinases (MKKs), MKK4/5/7/9, are capable of perturbing stomatal development and that these kinases comprise two pairs, MKK4/5 and MKK7/9, with both overlapping and divergent functions. We characterized the contributions of specific structural domains of these four "stomatal" MKKs to MAPK signaling output and specificity both in vitro and in vivo within the three discrete cell types of the stomatal lineage. These results verify the influence of functional docking (D) domains of MKKs on MAPK signal output and identify novel regulatory functions for previously uncharacterized structures within the N termini of MKK4/5. Beyond this, we present a novel function of the D-domains of MKK7/9 in regulating the subcellular localization of these kinases. These results provide tools to broadly assess the extent to which these and additional motifs within MKKs function to regulate MAPK signal output throughout the plant.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.