Trial reportSleep medicine2014
Increases in duration of first uninterrupted sleep period are associated with improvements in PSQI-measured sleep quality.
Trial report in Sleep medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00477490 (A Randomized, Double Blind, Placebo Controlled, Parallel Group, Multi-Center Study With a Double Blind Extension Investigating the Efficacy and Safety of a Fast- Dissolving), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Double Blind, Placebo Controlled, Parallel Group, Multi-Center Study With a Double Blind Extension Investigating the Efficacy and Safety of a Fast- Dissolving ("Melt") Formulation of Desmopressin for the Treatment of Nocturia in Adults
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- A systematic review and meta-analysis of acoustic stimulation in the treatment of insomnia.Frontiers in neuroscience · 2025Pooled it
- Deciphering Sleepless Nights: Nocturia Analyzed Through a CART-Based Predictive Model in Patients With Insomnia. Retrospective Data From the TUCSON Study.Neurourology and urodynamics · 2026Observational
- Association between light exposure and sleep problems related to nocturia in older adults: the Nagahama study.Journal of physiological anthropology · 2026Article
- The mediating effect of sleep quality in the relationship between nocturia and psychosocial functions in nurses: a cross-sectional survey based on TARGET.BMC nursing · 2025Article
- Effects of sleep duration and sleep quality in early pregnancy and their interaction on gestational diabetes mellitus.Sleep & breathing = Schlaf & Atmung · 2022Article
- Sleep quality, neurocognitive performance, and memory self-appraisal in middle-aged and older adults with memory complaints.International psychogeriatrics · 2021Article
- Prevalence and associated factors of DSM-5 insomnia disorder in the general population of Qatar.BMC psychiatry · 2021Article
- Article
- Overnight Urge Perception in Nocturia Is Independent of Depression, PTSD, or Anxiety in a Male Veterans Administration Population.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Inter-relationship between sleep quality, insomnia and sleep disorders in professional soccer players.BMJ open sport & exercise medicine · 2019Article
- Association of the combination of sleep duration and sleep quality with quality of life in type 2 diabetes patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2018Article
- Nocturnal Polyuria in Older Women with Urge Urinary Incontinence: Role of Sleep Quality, Time in Bed and Medications Used.The Journal of urology · 2017Article
- Nocturia: aetiology and treatment in adults.Nature reviews. Urology · 2016Review
- Nocturia: The circadian voiding disorder.Investigative and clinical urology · 2016Review
- Interaction of Sleep Duration and Sleep Quality on Hypertension Prevalence in Adult Chinese Males.Journal of epidemiology · 2015Article
- Pharmacologic management of nocturnal polyuria: a contemporary assessment of efficacy, safety, and progress toward individualized treatment.Therapeutic advances in urologyReview
- Sleep and Inflammation During Adolescence.Psychosomatic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveUrology clinical trials assessing bladder function have relied on the self-reported duration of the first uninterrupted sleep period (FUSP) as a proxy outcome for sleep, but the relationship between this measure and more conventional self-reported measures of sleep is unknown. In this study, we examined the association between changes in FUSP and a widely used self-reported measure of sleep, the Pittsburgh Sleep Quality Index (PSQI).
methodsWe conducted post hoc (secondary) analyses of unpublished data from a previously published randomized clinical trial (NCT00477490) of desmopressin (a medication used to treat nocturia) and examined relationships between baseline and 4-week change in FUSP and PSQI global and subscale scores for participants (N = 580 to N = 606) having complete data.
resultsData indicated strong associations between change in PSQI global score and FUSP change in six of seven subscale scores. A reduction of 1.8 points in the PSQI global score was associated with a 72-min lengthening of FUSP.
conclusionsResults suggest that FUSP is a potentially valuable metric that correlates with changes in perceived sleep duration, depth, quality for the entire night, efficiency, latency, and daytime function. An increase in FUSP was related to improvement in nearly all PSQI subscales. The validity of this measure in the general population remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.