ArticleTrends in genetics : TIG2014
Alternative splicing regulation of telomerase: a new paradigm?
Article in Trends in genetics : TIG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
54 citing papers in PubMed, 91 citations in OpenAlex.
- The role of telomerase reverse transcriptase in the mitochondrial protective functions of Angiotensin-(1-7) in diabetic CD34Biochemical pharmacology · 2024Article
- Comprehensive molecular analysis of immortalization hallmarks in thyroid cancer reveals new prognostic markers.Clinical and translational medicine · 2022Article
- Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care.Scientific reports · 2022Article
- Immunohistochemical and mutational status of telomerase reverse transcriptase in conjunctival squamous cell carcinoma.Indian journal of ophthalmology · 2022Article
- Noncanonical Role of Telomerase in Regulation of Microvascular Redox Environment With Implications for Coronary Artery Disease.Function (Oxford, England) · 2022Article
- Telomeres and Cancer.Life (Basel, Switzerland) · 2021Review
- Telomeres and Age-Related Diseases.Biomedicines · 2021Review
- Telomere associated gene expression as well as TERT protein level and telomerase activity are altered in the ovarian follicles of aged mice.Scientific reports · 2021Article
- Splicing alterations in healthy aging and disease.Wiley interdisciplinary reviews. RNA · 2021Review
- Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction.Cell reports · 2021Article
- Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes.Biomedicines · 2021Review
- Telomerase Regulation: A Role for Epigenetics.Cancers · 2021Review
- Mechanism of recognition of parallel G-quadruplexes by DEAH/RHAU helicase DHX36 explored by molecular dynamics simulations.Computational and structural biotechnology journal · 2021Article
- RBM10 regulates human TERT gene splicing and inhibits pancreatic cancer progression.American journal of cancer research · 2021Article
- Properties and biological impact of RNA G-quadruplexes: from order to turmoil and back.Nucleic acids research · 2020Article
- Composition and Function of Telomerase-A Polymerase Associated with the Origin of Eukaryotes.Biomolecules · 2020Review
- Article
- Telomerase and CD4 T Cell Immunity in Cancer.Cancers · 2020Review
- Review
- Telomerase Reverse Transcriptase (TERT) Regulation in Thyroid Cancer: A Review.Frontiers in endocrinology · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Alternative splicing affects approximately 95% of eukaryotic genes, greatly expanding the coding capacity of complex genomes. Although our understanding of alternative splicing has increased rapidly, current knowledge of splicing regulation has largely been derived from studies of highly expressed mRNAs. Telomerase is a key example of a protein that is alternatively spliced, but it is expressed at very low levels and although it is known that misregulation of telomerase splicing is a hallmark of nearly all cancers, the details of this process are unclear. Here we review work showing that hTERT expression is in part regulated by atypical alternative splicing, perhaps due to its exceptionally low expression level. We propose that these differential regulatory mechanisms may be widely applicable to other genes and may provide new opportunities for the development of cancer therapeutics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.