ArticleSurgical endoscopy2015
Laparoscopic appendectomy versus open appendectomy in pregnancy: a population-based analysis of maternal outcome.
Article in Surgical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 7 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Trimester-specific safety of laparoscopic versus open abdominal surgery during pregnancy: systematic review and meta-analysis.The British journal of surgery · 2026Pooled it
- SAGES guidelines for the use of laparoscopy during pregnancy.Surgical endoscopy · 2024Guideline
- EAES rapid guideline: systematic review, meta-analysis, GRADE assessment, and evidence-informed European recommendations on appendicitis in pregnancy.Surgical endoscopy · 2022Guideline
- Updated Evaluation of Laparoscopic vs. Open Appendicectomy During Pregnancy: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Laparoscopic appendectomy versus open appendectomy for suspected appendicitis during pregnancy: a systematic review and updated meta-analysis.BMC surgery · 2019Pooled it
- Is the laparoscopic approach a safe choice for the management of acute appendicitis in pregnant women? A meta-analysis of observational studies.Annals of the Royal College of Surgeons of England · 2019Pooled it
- Evidence-Based Guideline on Laparoscopy in Pregnancy: Commissioned by the British Society for Gynaecological Endoscopy (BSGE) Endorsed by the Royal College of Obstetricians & Gynaecologists (RCOG).Facts, views & vision in ObGyn · 2019Pooled it
- A Multicenter Collaborative Study on the Safety and Efficacy of Laparoscopic Appendectomy During Pregnancy.Annals of gastroenterological surgery · 2026Article
- Case Report: ERAT-based management of appendiceal abscess in early pregnancy.Frontiers in surgery · 2026Article
- Acute appendicitis during pregnancy: a case-control study.Frontiers in surgery · 2026Article
- Perforated peptic ulcer in pregnancy and puerperium: A systematic review.World journal of gastrointestinal surgery · 2025Article
- Impact of gestational age on the management of acute appendicitis during pregnancy: A nationwide observational study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Observational
- Management of acute appendicitis in pregnancy (MAMA): Protocol for a multicentre observational study.PloS one · 2025Article
- The Association of Polish Surgeons (APS) clinical guidelines for the use of laparoscopy in the management of abdominal emergencies. Part II.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2023Article
- Open versus laparoscopic appendectomy for acute appendicitis in pregnancy: a population-based study.Surgical endoscopy · 2023Article
- Clinical Characteristics of Acute Appendicitis in Pregnancy: 10-Year Experience at a Single Institution in South Korea.Journal of clinical medicine · 2023Article
- Management of Complicated Appendicitis During Pregnancy in the US.JAMA network open · 2022Article
- Pregnant patients requiring appendectomy: comparison between open and laparoscopic approaches in NY State.Surgical endoscopy · 2021Article
- Laparoscopic treatment for appendicitis during pregnancy: Retrospective cohort study.Annals of medicine and surgery (2012) · 2021Article
- Safety of laparoscopic appendectomy for the management of acute appendicitis during pregnancy.Journal of minimally invasive surgery · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLaparoscopic appendectomy (LA) is the standard treatment of acute appendicitis for the general population; however, there is still some doubt regarding its safety for pregnant patients. Therefore, the purpose of this study is to investigate and compare the maternal outcome of pregnant patients with acute appendicitis following either an open appendectomy (OA) or LA from a population-based database.
methodsThis study is based on the National Health Insurance Research Database. Patients with both ICD-9-CM codes for appendicitis (540.9, 540.0, and 540.1) and pregnancy (V22) in the same admission were considered to have acute appendicitis during pregnancy. These patients were divided into three groups according to the type of treatment: LA, OA, and non-operative treatment. Outcome measures that were compared between the groups included maternal complications such as preterm labor, abortion, and the need of cesarean section. Besides, the differences of medical expenditure and length of hospital stay between the groups were also analyzed.
resultsFrom 2005 to 2010, a total of 859 pregnant women who had acute appendicitis were identified. They had increased risks for preterm labor, abortion, and increased requirement of cesarean section compared to the control group (i.e., those without acute appendicitis). Among the three groups, the non-operated group has the highest risk of preterm labor. Patients who underwent LA did not have any increased risk of maternal complications compared to the OA group. Furthermore, LA patients had shorter hospital stay than OA.
conclusionCompared to non-operative treatment, appendectomy is the preferred treatment for pregnant patients who have acute appendicitis. LA can be performed safely in pregnant patients without bringing additional maternal complications compared to OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.