ArticleSchizophrenia research2014
Testing trait depression as a potential clinical domain in schizophrenia.
Article in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Cognitive functions in schizophrenia: the interplay between blood viscosity, serum osmolarity, and symptom severity.BMC psychiatry · 2025Article
- The bidirectional relationship between depression and perceived social support among college freshmen: evidence from longitudinal and daily diary methods.Frontiers in psychology · 2025Article
- A systematic review of structural and functional magnetic resonance imaging studies on the neurobiology of depressive symptoms in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2024Review
- Psychotic spectrum features in borderline and bipolar disorders within the scope of the DSM-5 section III personality traits: a case control study.Borderline personality disorder and emotion dysregulation · 2023Article
- Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort.JAMA psychiatry · 2022Article
- Review
- Network Analysis of the Relationship Between Trait Depression and Impulsiveness Among Youth.Frontiers in psychiatry · 2022Article
- Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in severe mental illness in the Paisa population: a case-control study.The lancet. Psychiatry · 2020Article
- Clinical Correlates of Insulin Resistance in Chronic Schizophrenia: Relationship to Negative Symptoms.Frontiers in psychiatry · 2019Article
- Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups From Widely Available Symptom Data.Schizophrenia bulletin · 2018Article
- Comorbid Moderate-Severe Depressive Symptoms and their Association with Quality of Life in Chinese Patients with Schizophrenia Treated in Primary Care.Community mental health journal · 2016Article
- Evaluation of Myo-Inositol as a Potential Biomarker for Depression in Schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Frontiers in psychiatry · 2015Review
- Perils of Pragmatic Psychiatry: How We Can Do Better.HSOA journal of psychiatry, depression & anxietyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The DSM-5 includes depression as a dimension of psychosis. We tested whether persistent experience of depression, called 'trait depression', is a clinical feature separate from psychosis and several well-known, trait-like deficits of schizophrenia. 126 individuals with schizophrenia and 151 control participants completed the Maryland Trait and State Depression questionnaire, with a subset completing measures of cognition and functional capacity, and diffusion tensor imaging (n=73 patients and 102 controls for imaging analysis). Subjectively experienced, longitudinal trait depression is significantly higher in patients with schizophrenia compared with controls. Higher trait depression scores were associated with more severe psychosis. Surprisingly, individuals with higher trait depression manifested less cognitive and global functioning deficits. In addition, trait depression scores were positively associated with fractional anisotropy of white matter. Trait depression appears to be a highly relevant clinical domain in the care of patients with schizophrenia that also has distinct relationships with some other known traits of the disease. Trait depression may be an important contributor to the clinical heterogeneity of schizophrenia.
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Registered trials
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