ArticleCell2014
An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists.
Article in Cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed.
- Sugar Metabolisms Altered By Undissociated Forms of Organic Acids Based on the Emergence of [GARYeast (Chichester, England) · 2026Article
- Article
- The Prion-Like Properties of the INO80 Chromatin Remodeler Regulate Metabolic Gene Expression.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary cell biology comes of age.Journal of cell science · 2025Article
- Spontaneous Attenuation of Alcoholic Fermentation via the Dysfunction of Cyc8p inInternational journal of molecular sciences · 2023Article
- How Big Is the Yeast Prion Universe?International journal of molecular sciences · 2023Review
- Yeast Chaperone Hsp70-Ssb Modulates a Variety of Protein-Based Heritable Elements.International journal of molecular sciences · 2023Article
- A novel narnavirus is widespread in Saccharomyces cerevisiae and impacts multiple host phenotypes.G3 (Bethesda, Md.) · 2023Article
- In Situ Sprayed Biotherapeutic Gel Containing Stable Microbial Communities for Efficient Anti-Infection Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Quiescence inAnnual review of genetics · 2022Review
- Truth in wine yeast.Microbial biotechnology · 2022Review
- Diversity of bet-hedging strategies in microbial communities-Recent cases and insights.WIREs mechanisms of disease · 2022Review
- The Ecology and Evolution of the Baker's YeastGenes · 2022Review
- Phenotypic plasticity as a facilitator of microbial evolution.Environmental epigenetics · 2022Review
- Article
- Mechanisms Involved in Interspecific Communication between Wine Yeasts.Foods (Basel, Switzerland) · 2021Review
- FUS and TDP-43 Phases in Health and Disease.Trends in biochemical sciences · 2021Review
- Protein aggregation and the evolution of stress resistance in clinical yeast.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The Hunt for Ancient Prions: Archaeal Prion-Like Domains Form Amyloid-Based Epigenetic Elements.Molecular biology and evolution · 2021Article
- Protein self-assembly: A new frontier in cell signaling.Current opinion in cell biology · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
[GAR(+)] is a protein-based element of inheritance that allows yeast (Saccharomyces cerevisiae) to circumvent a hallmark of their biology: extreme metabolic specialization for glucose fermentation. When glucose is present, yeast will not use other carbon sources. [GAR(+)] allows cells to circumvent this "glucose repression." [GAR(+)] is induced in yeast by a factor secreted by bacteria inhabiting their environment. We report that de novo rates of [GAR(+)] appearance correlate with the yeast's ecological niche. Evolutionarily distant fungi possess similar epigenetic elements that are also induced by bacteria. As expected for a mechanism whose adaptive value originates from the selective pressures of life in biological communities, the ability of bacteria to induce [GAR(+)] and the ability of yeast to respond to bacterial signals have been extinguished repeatedly during the extended monoculture of domestication. Thus, [GAR(+)] is a broadly conserved adaptive strategy that links environmental and social cues to heritable changes in metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.