ArticleThe ISME journal2015
Species specificity of symbiosis and secondary metabolism in ascidians.
Article in The ISME journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Article
- Didemnosides A and B: Antiproliferative Nucleosides from the Red Sea Marine TunicateMarine drugs · 2025Article
- Metabolites Obtained from Boraginaceae Plants as Potential Cosmetic Ingredients-A Review.Molecules (Basel, Switzerland) · 2024Review
- Exploring the secrets of marine microorganisms: Unveiling secondary metabolites through metagenomics.Microbial biotechnology · 2024Review
- Effects of color variation and physiological state on ascidian microbiomes.MicrobiologyOpen · 2024Article
- An organic extract from ascidianFrontiers in chemistry · 2024Article
- Article
- Impact of Marine Chemical Ecology Research on the Discovery and Development of New Pharmaceuticals.Marine drugs · 2023Review
- Effects of temperature on the interaction between amphibian skin bacteria andFrontiers in microbiology · 2023Article
- Physiological changes during torpor favor association withFrontiers in microbiology · 2023Article
- Enhanced anaerobic digestion of dairy wastewater in a granular activated carbon amended sequential batch reactor.Global change biology. Bioenergy · 2022Article
- Possible Functional Roles of Patellamides in the Ascidian-Marine drugs · 2022Review
- Antibacterial Bicyclic Fatty Acids from a Korean Colonial TunicateMarine drugs · 2021Article
- Taxonomic Composition and Biological Activity of Bacterial Communities Associated with Marine Ascidians from Andaman Islands, India.Applied biochemistry and biotechnology · 2021Article
- Symbiotic Associations in Ascidians: Relevance for Functional Innovation and Bioactive Potential.Marine drugs · 2021Review
- Existence in cellulose shelters: industrial and pharmaceutical leads of symbiotic actinobacteria from ascidian Phallusia nigra, Andaman Islands.World journal of microbiology & biotechnology · 2021Article
- Marine Natural Products from Tunicates and Their Associated Microbes.Marine drugs · 2021Review
- Symbioses of Cyanobacteria in Marine Environments: Ecological Insights and Biotechnological Perspectives.Marine drugs · 2021Review
- Antifouling Activity of Meroterpenes Isolated from the Ascidian Aplidium aff. densum.Marine biotechnology (New York, N.Y.) · 2021Article
- Microbiome Variability across the Native and Invasive Ranges of the Ascidian Clavelina oblonga.Applied and environmental microbiology · 2021Article
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8 authors.
Funding
Abstract
Ascidians contain abundant, diverse secondary metabolites, which are thought to serve a defensive role and which have been applied to drug discovery. It is known that bacteria in symbiosis with ascidians produce several of these metabolites, but very little is known about factors governing these 'chemical symbioses'. To examine this phenomenon across a wide geographical and species scale, we performed bacterial and chemical analyses of 32 different ascidians, mostly from the didemnid family from Florida, Southern California and a broad expanse of the tropical Pacific Ocean. Bacterial diversity analysis showed that ascidian microbiomes are highly diverse, and this diversity does not correlate with geographical location or latitude. Within a subset of species, ascidian microbiomes are also stable over time (R=-0.037, P-value=0.499). Ascidian microbiomes and metabolomes contain species-specific and location-specific components. Location-specific bacteria are found in low abundance in the ascidians and mostly represent strains that are widespread. Location-specific metabolites consist largely of lipids, which may reflect differences in water temperature. By contrast, species-specific bacteria are mostly abundant sequenced components of the microbiomes and include secondary metabolite producers as major components. Species-specific chemicals are dominated by secondary metabolites. Together with previous analyses that focused on single ascidian species or symbiont type, these results reveal fundamental properties of secondary metabolic symbiosis. Different ascidian species have established associations with many different bacterial symbionts, including those known to produce toxic chemicals. This implies a strong selection for this property and the independent origin of secondary metabolite-based associations in different ascidian species. The analysis here streamlines the connection of secondary metabolite to producing bacterium, enabling further biological and biotechnological studies.
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