ArticlePloS one2014
Circulating progenitor cells and vascular dysfunction in chronic obstructive pulmonary disease.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Fibrinogen is a promising biomarker for chronic obstructive pulmonary disease: evidence from a meta-analysis.Bioscience reports · 2020Pooled it
- Circulating hematopoietic stem/progenitor cell subsets contribute to human hematopoietic homeostasis.Blood · 2024Trial
- Impaired training-induced adaptation of blood pressure in COPD patients: implication of the muscle capillary bed.International journal of chronic obstructive pulmonary disease · 2016Trial
- Endothelial Progenitor Cells: Disease Markers and Potential Therapy in Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025Review
- Endothelial progenitor cells and chronic obstructive pulmonary disease: From basic research to clinical application.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Stem cell therapy in pulmonary hypertension: current practice and future opportunities.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article.Life (Basel, Switzerland) · 2022Review
- Review
- Endothelial dysfunction in COPD: a systematic review and meta-analysis of studies using different functional assessment methods.ERJ open research · 2021Review
- Cigarette smoke extract affects methylation status and attenuates Sca-1 expression of mouse endothelial progenitor cell in vitro.Tobacco induced diseases · 2021Article
- Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Association Between Systemic and Pulmonary Vascular Dysfunction in COPD.International journal of chronic obstructive pulmonary disease · 2020Article
- Progenitor cell mobilisation and recruitment in pulmonary arteries in chronic obstructive pulmonary disease.Respiratory research · 2019Article
- Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease.Archives of medical science : AMS · 2018Article
- Imbalance between endothelial damage and repair capacity in chronic obstructive pulmonary disease.PloS one · 2018Article
- Cyp2c44-mediated decrease of 15-HETE exacerbates pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2017Article
- CD133+ cells are associated with ADIPOCYTOKINES and endothelial dysfunction in hemodialysis patients.BMC nephrology · 2017Article
- The role of bone marrow-derived endothelial progenitor cells and angiogenic responses in chronic obstructive pulmonary disease.Journal of thoracic disease · 2017Review
- Cigarette smoke challenges bone marrow mesenchymal stem cell capacities in guinea pig.Respiratory research · 2017Article
- The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD).Respiratory research · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn chronic obstructive pulmonary disease (COPD), decreased progenitor cells and impairment of systemic vascular function have been suggested to confer higher cardiovascular risk. The origin of these changes and their relationship with alterations in the pulmonary circulation are unknown.
objectivesTo investigate whether changes in the number of circulating hematopoietic progenitor cells are associated with pulmonary hypertension or changes in endothelial function.
methods62 COPD patients and 35 controls (18 non-smokers and 17 smokers) without cardiovascular risk factors other than cigarette smoking were studied. The number of circulating progenitors was measured as CD45(+)CD34(+)CD133(+) labeled cells by flow cytometry. Endothelial function was assessed by flow-mediated dilation. Markers of inflammation and angiogenesis were also measured in all subjects.
resultsCompared with controls, the number of circulating progenitor cells was reduced in COPD patients. Progenitor cells did not differ between control smokers and non-smokers. COPD patients with pulmonary hypertension showed greater number of progenitor cells than those without pulmonary hypertension. Systemic endothelial function was worse in both control smokers and COPD patients. Interleukin-6, fibrinogen, high sensitivity C-reactive protein, vascular endothelial growth factor and tumor necrosis factor were increased in COPD. In COPD patients, the number of circulating progenitor cells was inversely related to the flow-mediated dilation of systemic arteries.
conclusionsPulmonary and systemic vascular impairment in COPD is associated with cigarette smoking but not with the reduced number of circulating hematopoietic progenitors. The latter appears to be a consequence of the disease itself not related to smoking habit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.