ArticleMolecular medicine (Cambridge, Mass.)2015
Reduction of cardiac cell death after helium postconditioning in rats: transcriptional analysis of cell death and survival pathways.
Article in Molecular medicine (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Reply to Trela, B.A.; Guffroy, M.R. Comment on "AlAsmari et al. Venetoclax Induces Cardiotoxicity Through Modulation of Oxidative-Stress-Mediated Cardiac Inflammation and Apoptosis via NF-κB and BCL-2 Pathway.International journal of molecular sciences · 2026Article
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- Gasotransmitters and noble gases in cardioprotection: unraveling molecular pathways for future therapeutic strategies.Basic research in cardiology · 2024Review
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- Experimental Conditions That Influence the Utility of 2'7'-Dichlorodihydrofluorescein Diacetate (DCFHAntioxidants (Basel, Switzerland) · 2022Article
- Optimal Use of 2',7'-Dichlorofluorescein Diacetate in Cultured Hepatocytes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Noble Gases Therapy in Cardiocerebrovascular Diseases: The Novel Stars?Frontiers in cardiovascular medicine · 2022Review
- Potassium Alginate Oligosaccharides Alter Gut Microbiota, and Have Potential to Prevent the Development of Hypertension and Heart Failure in Spontaneously Hypertensive Rats.International journal of molecular sciences · 2021Article
- Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons.Intensive care medicine experimental · 2019Review
- Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection.International journal of molecular sciences · 2019Article
- Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats.Investigative ophthalmology & visual science · 2016Article
- IL-23 and IL-17A are not involved in hepatic/ischemia reperfusion injury in mouse and man.Journal of clinical and translational research · 2015Article
- Advances in molecular mechanism of cardioprotection induced by helium.Medical gas researchReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemia/reperfusion (I/R) it was shown that helium conditioning reduces infarct size. Currently, it is not known how helium exerts its cytoprotective effects and which cell death/survival pathways are affected. The objective of this study, therefore, was to investigate the cell protective effects of helium postconditioning by PCR array analysis of genes involved in necrosis, apoptosis and autophagy. Male rats were subjected to 25 min of ischemia and 5, 15 or 30 min of reperfusion. Semiquantitative histological analysis revealed that 15 min of helium postconditioning reduced the extent of I/R-induced cell damage. This effect was not observed after 5 and 30 min of helium postconditioning. Analysis of the differential expression of genes showed that 15 min of helium postconditioning mainly caused upregulation of genes involved in autophagy and inhibition of apoptosis versus I/R alone. The results suggest that the cytoprotective effects of helium inhalation may be caused by a switch from pro-cell-death signaling to activation of cell survival mechanisms, which appears to affect a wide range of pathways.
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