ReviewGerontology2014
Proinflammation of aging central arteries: a mini-review.
Review in Gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Increased cell stiffness contributes to complement-mediated injury of choroidal endothelial cells in a monkey model of early age-related macular degeneration.The Journal of pathology · 2022Article
- Could angiotensin-II induced T-cell senescence exacerbate age-related vascular dysfunction?The Journal of physiology · 2022Article
- Extracellular Matrix in Aging Aorta.Frontiers in cell and developmental biology · 2022Review
- Age-associated proinflammatory elastic fiber remodeling in large arteries.Mechanisms of ageing and development · 2021Review
- Angiotensin II, Hypercholesterolemia, and Vascular Smooth Muscle Cells: A Perfect Trio for Vascular Pathology.International journal of molecular sciences · 2020Review
- COVID-19-Related Stroke.Translational stroke research · 2020Article
- mTOR and Aging: An Old Fashioned Dress.International journal of molecular sciences · 2019Review
- Article
- Impact of Sex Differences and Diabetes on Coronary Atherosclerosis and Ischemic Heart Disease.Journal of clinical medicine · 2019Review
- Intersection between gonadal function and vascular aging in women.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Angiotensin II- and Alzheimer-Type Cardiovascular Aging.Circulation research · 2018Article
- Cellular mechanisms underlying obesity-induced arterial stiffness.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Review
- Is Vascular Amyloidosis Intertwined with Arterial Aging, Hypertension and Atherosclerosis?Frontiers in genetics · 2017Review
- Aging: Molecular Pathways and Implications on the Cardiovascular System.Oxidative medicine and cellular longevity · 2017Review
- Chronic p38 mitogen-activated protein kinase inhibition improves vascular function and remodeling in angiotensin II-dependent hypertension.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2016Article
- "Inflammaging" as a Druggable Target: A Senescence-Associated Secretory Phenotype-Centered View of Type 2 Diabetes.Oxidative medicine and cellular longevity · 2016Review
- Vascular biology of ageing-Implications in hypertension.Journal of molecular and cellular cardiology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Arterial aging is a cornerstone of organismal aging. The central arterial wall structurally and functionally remodels under chronic proinflammatory stress over a lifetime. The low-grade proinflammation that accompanies advancing age causes arterial wall thickening and stiffening. These structural and functional alterations are consequences of adverse molecular and cellular events, e.g. an increase in local angiotensin II signaling that induces an inflammatory phenotypic shift of endothelial and smooth muscle cells. Thus, interventions to restrict proinflammatory signaling are a rational approach to delay or prevent age-associated adverse arterial remodeling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.