Evidence map›Paper›PMID 25170994›Full record

Trial reportAddiction (Abingdon, England)2015

HERMITAGE--a randomized controlled trial to reduce sexually transmitted infections and HIV risk behaviors among HIV-infected Russian drinkers.

Jeffrey H Samet, Anita Raj, Debbie M Cheng, Elena Blokhina, Carly Bridden, Christine E Chaisson, Alexander Y Walley, Tibor P Palfai, Emily K Quinn, Edwin Zvartau and 2 more

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Addiction (Abingdon, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 10 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 10 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  4. Complex solutions for a complex problem: A meta-analysis of the efficacy of multiple-behavior interventions on change in outcomes related to HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021
    Pooled it
  5. More behavioral recommendations produce more change: A meta-analysis of efficacy of multibehavior recommendations to reduce nonmedical substance use.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020
    Pooled it
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  11. Trial
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  15. Review
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  17. Prevalence of Alcohol Use and Factors Associated With Problem Drinking in Social Networks of People Living With HIV Infection in St. Petersburg, Russia.AIDS education and prevention : official publication of the International Society for AIDS Education · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Jeffrey H SametDepartment of Medicine, Section of General Internal Medicine, Clinical Addiction Research and Education (CARE) Unit, Boston University School of Medicine/Boston Medical Center, Boston, MA, USA; Department of Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.
Anita Raj
Debbie M Cheng
Elena Blokhina
Carly Bridden
Christine E Chaisson
Alexander Y Walley
Tibor P Palfai
Emily K Quinn
Edwin Zvartau
Dmitry Lioznov
Evgeny Krupitsky
Boston University · USFirst Pavlov State Medical University of St. Petersburg · RUBoston Medical Center · USSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RUUniversity of California, San Diego · US

Funding

Neuropathology CoreP30AG013846 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOWALL, NEIL W. · 1996 to 2020
$29.1M
URBAN ARCH (2/5) Biostatistics and Data Management Core (BDM)U24AA020779 · NIAAA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CHENG, DEBBIE M. · 2011 to 2020
$3.6M
URBAN ARCH (1/5) Administrative Coordinating Core (Admin Core)U24AA020778 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2011 to 2020
$3.5M
Maximizing Opportunity - HIV Prevention in Hospitalized Russian DrinkersR01AA016059 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2006 to 2010
$3.2M
Impact of Alcohol Use on HIV Infection--In the United States and RussiaK24AA015674 · NIAAA · BOSTON MEDICAL CENTER · PI SAMET, JEFFREY H. · 2006 to 2010
$756k
NIAAA NIH HHS K24 AA015674NIAAA NIH HHS K24AA015674NIAAA NIH HHS R01 AA016059NIAAA NIH HHS R01AA016059NIAAA NIH HHS U24 AA020778NIAAA NIH HHS U24AA020778NIAAA NIH HHS U24 AA020779NIAAA NIH HHS U24AA020779NIA NIH HHS P30 AG013846
6 · The paper itself

Abstract

aimsThis study assessed the effectiveness of HERMITAGE (HIV's Evolution in Russia-Mitigating Infection Transmission and Alcoholism in a Growing Epidemic), an adapted secondary HIV prevention intervention, compared with an attention control condition in decreasing sexually transmitted infections (STIs) and sex and drug risk behaviors among Russian HIV-infected heavy drinkers.

designWe conducted a single-blinded, two-armed, randomized controlled trial with 12-month follow-up.

settingThe study was conducted in St Petersburg, Russia. Participants were recruited from four HIV and addiction clinical sites. The intervention was conducted at Botkin Infectious Disease Hospital.

participantsHIV-infected individuals with past 6-month risky sex and heavy alcohol consumption (n = 700) were randomized to the HERMITAGE intervention (n = 350) or an attention control condition (n = 350).

interventionA Healthy Relationships Intervention stressing disclosure of HIV serostatus and condom use, adapted for a Russian clinical setting with two individual sessions and three small group sessions. MEASUREMENTS: The primary outcome was incident STI by laboratory test at 12-month follow-up. Secondary outcomes included change in unprotected sex and several alcohol and injection drug use (IDU) variables.

findingsParticipants had the following baseline characteristics: 59.3% male, mean age 30.1, 60.4% past year IDU, 15.4% prevalent STI and mean CD4 cell count 413.3/μl. Assessment occurred among 75 and 71% of participants at 6 and 12 months, respectively. STIs occurred in 20 subjects (8.1%) in the intervention group and 28 subjects (12.0%) in the control group at 12-month follow-up; logistic regression analyses found no significant difference between groups (adjusted odds ratio 0.63; 95% confidence interval = 0.34-1.18; P = 0.15). Both groups decreased unsafe behaviors, although no significant differences were found between groups.

conclusionsThe HERMITAGE HIV risk reduction intervention does not appear to reduce sexually transmitted infections and HIV risk behaviors in Russian HIV-infected heavy drinkers compared with attention controls.

Indexed as

AdultAlcohol DrinkingCondomsFemaleHIV InfectionsHumansMalePsychotherapyRisk Reduction BehaviorRisk-TakingRussiaSecondary PreventionSexually Transmitted DiseasesSingle-Blind MethodTreatment OutcomeUnsafe SexHealthy relationshipsHIV risk behaviorsRCTRussian HIVSTIsubstance users

Identifiers

PMID25170994
PMCPMC4270840
OpenAlexW1599558717

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.