Trial reportPloS one2014
The synergistic effect of functional status and comorbidity burden on mortality: a 16-year survival analysis.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- The Minimal assessment Protocol for Cerebral Stroke 2020 (PMIC2020): a multicenter feasibility study in post-stroke inpatient rehabilitation.European journal of physical and rehabilitation medicine · 2024Observational
- Combined use of the Clinical Frailty Scale and laboratory tests in acutely hospitalized older patients.Aging clinical and experimental research · 2023Observational
- Article
- Cross-validation of predictive models for functional recovery after post-stroke rehabilitation.Journal of neuroengineering and rehabilitation · 2022Article
- Characteristics and mortality rates among patients requiring intermediate care: a national cohort study using linked databases.BMC medicine · 2021Article
- Medical foster home is less costly than traditional nursing home care.Health services research · 2019Article
- Association Between Symptom Burden and Physical Function in Older Patients with Cancer.Journal of the American Geriatrics Society · 2019Article
- The Long-Term Impact of Functional Disability on Hospitalization Spending in Singapore.Journal of the economics of ageing · 2019Article
- Changes of a frailty index based on common blood and urine tests during a hospital stay on geriatric wards predict 6-month and 1-year mortality in older people.Clinical interventions in aging · 2019Article
- Distinct Physical Function Profiles in Older Adults Receiving Cancer Chemotherapy.Journal of pain and symptom management · 2017Article
- Financing Long-Term Services and Supports: Ideas From Singapore.The Milbank quarterly · 2017Article
- Operationalizing a frailty index using routine blood and urine tests.Clinical interventions in aging · 2017Article
- Comparing the predictive accuracy of frailty, comorbidity, and disability for mortality: a 1-year follow-up in patients hospitalized in geriatric wards.Clinical interventions in aging · 2017Article
- Race-based disparities in loss of functional independence after hysterectomy for uterine cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
- A comparison of Frailty Indexes Based on a Comprehensive Geriatric Assessment for the Prediction of Adverse Outcomes.The journal of nutrition, health & aging · 2016Article
- Analysis of Rockwood et Al's Clinical Frailty Scale and Fried et Al's Frailty Phenotype as Predictors of Mortality and Other Clinical Outcomes in Older Patients Who Were Admitted to a Geriatric Ward.The journal of nutrition, health & aging · 2015Article
- Admission vitamin D status is associated with discharge destination in critically ill surgical patients.Annals of intensive care · 2015Article
- Cross-sectional study of the association between functional status and acute kidney injury in geriatric patients.BMC nephrology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe relationship between disability and comorbidity on mortality is widely perceived as additive in clinical models of frailty.
designNational data were retrospectively extracted from medical records of community hospital. DATA SOURCES: There were of 12,804 acutely-disabled patients admitted for inpatient rehabilitation in Singapore rehabilitation community hospitals from 1996 through 2005 were followed up for death till 31 December 2011. OUTCOME MEASURE: Cox proportional-hazards regression to assess the interaction of comorbidity and disability at discharge on all-cause mortality.
resultsDuring a median follow-up of 10.9 years, there were 8,565 deaths (66.9%). The mean age was 73.0 (standard deviation: 11.5) years. Independent risk factors of mortality were higher comorbidity (p<0.001), severity of disability at discharge (p<0.001), being widowed (adjusted hazard ratio [aHR]: 1.38, 95% confidence interval [CI]:1.25-1.53), low socioeconomic status (aHR:1.40, 95%CI:1.29-1.53), discharge to nursing home (aHR:1.14, 95%CI:1.05-1.22) and re-admission into acute care (aHR:1.54, 95%CI:1.45-1.65). In the main effects model, those with high comorbidity had an aHR = 2.41 (95%CI:2.13-2.72) whereas those with total disability had an aHR = 2.28 (95%CI:2.12-2.46). In the interaction model, synergistic interaction existed between comorbidity and disability (p<0.001) where those with high comorbidity and total disability had much higher aHR = 6.57 (95%CI:5.15-8.37).
conclusionsPatients with greater comorbidity and disability at discharge, discharge to nursing home or re-admission into acute care, lower socioeconomic status and being widowed had higher mortality risk. Our results identified predictive variables of mortality that map well onto the frailty cascade model. Increasing comorbidity and disability interacted synergistically to increase mortality risk.
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