ArticleChemical communications (Cambridge, England)2014
Monitoring ATP hydrolysis and ATPase inhibitor screening using (1)H NMR.
Article in Chemical communications (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 25 citations in OpenAlex.
- First-in-Class Covalent Inhibitors of PFKFB3: Discovery and Characterization in PDAC Models.Journal of medicinal chemistry · 2026Article
- Crystal structure of a covalently linked Aurora-A-MYCN complex.Acta crystallographica. Section D, Structural biology · 2023Article
- Reconstitution of an intact clock reveals mechanisms of circadian timekeeping.Science (New York, N.Y.) · 2021Article
- Combined in silico and 19F NMR analysis of 5-fluorouracil metabolism in yeast at low ATP conditions.Bioscience reports · 2019Article
- A generic HTS assay for kinase screening: Validation for the isolation of an engineered malate kinase.PloS one · 2018Article
- Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.Metabolomics : Official journal of the Metabolomic Society · 2017Article
- Assembly and turnover of short actin filaments by the formin INF2 and profilin.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We present a versatile method to characterize ATPase and kinase activities and discover new inhibitors of these proteins. The proton NMR-based assay directly monitors ATP turnover and is easy to implement, requires no additional reagents and can potentially be applied to GTP. We validated the method's accuracy, applied it to the monitoring of ATP turnover by actin and to the screening of ATPase inhibitors, and showed that it is also applicable for the monitoring of GTP hydrolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.