Evidence map›Paper›PMID 25170395›Full record

ReviewWorld journal of radiology2014

Pathophysiology, clinical features and radiological findings of differentiation syndrome/all-trans-retinoic acid syndrome.

Luciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Stefano Ulisciani, Carmen Fava, Giovanna Rege-Cambrin

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Differentiation Syndrome in a Patient With NSCLC HarboringJTO clinical and research reports · 2024
    Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Luciano CardinaleLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Francesco AsteggianoLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Federica MorettiLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Federico TorreLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Stefano UliscianiLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Carmen FavaLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Giovanna Rege-CambrinLuciano Cardinale, Francesco Asteggiano, Federica Moretti, Federico Torre, Institute of Radiology, Department of Clinical and Biological Sciences, University of Turin, AOU S.Luigi Gonzaga, 10043 Orbassano, Torino, Italy.
Ospedale San Luigi Gonzaga · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In acute promyelocytic leukemia, differentiation therapy based on all-trans-retinoic acid can be complicated by the development of a differentiation syndrome (DS). DS is a life-threatening complication, characterized by respiratory distress, unexplained fever, weight gain, interstitial lung infiltrates, pleural or pericardial effusions, hypotension and acute renal failure. The diagnosis of DS is made on clinical grounds and has proven to be difficult, because none of the symptoms is pathognomonic for the syndrome without any definitive diagnostic criteria. As DS can have subtle signs and symptoms at presentation but progress rapidly, end-stage DS clinical picture resembles the acute respiratory distress syndrome with extremely poor prognosis; so it is of absolute importance to be conscious of these complications and initiate therapy as soon as it was suspected. The radiologic appearance resembles the typical features of cardiogenic pulmonary edema. Diagnosis of DS remains a great skill for radiologists and haematologist but it is of an utmost importance the cooperation in suspect DS, detect the early signs of DS, examine the patients' behaviour and rapidly detect the complications.

Indexed as

Acute promyelocytic leukaemiaAll-trans-retinoic acid syndromeChest X-ray and computed tomographyDifferentiation syndromeLungleukemic infiltratesPromyelocytic leukemia/retinoic acid receptor-α

Identifiers

PMID25170395
PMCPMC4147438
OpenAlexW2144879611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.