Evidence map›Paper›PMID 25170298›Full record

ArticleInternational journal of medical sciences2014

Impact of single nucleotide polymorphism in IL-4, IL-4R genes and systemic concentration of IL-4 on the incidence of glioma in Iraqi patients.

Haidar A Shamran, Subah J Hamza, Nahi Y Yaseen, Ahmad A Al-Juboory, Dennis D Taub, Robert L Price, Mitzi Nagarkatti, Prakash S Nagarkatti, Udai P Singh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of medical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Haidar A Shamran1. Medical Research Unit, School of Medicine, University of AL-Nahrain Iraq, Baghdad ; 6. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
Subah J Hamza2. Biotechnology Department, School of Science, University of AL-Nahrain, Iraq, Baghdad.
Nahi Y Yaseen3. Iraqi National Cancer Center, University of AL-Mustansiriya, Iraq, Baghdad.
Ahmad A Al-Juboory4. Neuroscience Hospital, Neurosurgery, Iraq, Baghdad.
Dennis D Taub5. Center for Translational Studies, Medical Services, VA Medical Center, Department of Veteran Affairs, Washington DC, USA.
Robert L Price6. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
Mitzi Nagarkatti6. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
Prakash S Nagarkatti6. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
Udai P Singh6. Department of Pathology, Microbiology and Immunology, School of Medicine, University of South Carolina, SC, USA.
University of South Carolina · USNahrain University · IQBaghdad Medical City · IQMustansiriyah University · IQVeterans Health Administration · US

Funding

Targeting early ceramide elevation in pre-symptomatic eczemaP20GM103641 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI ENOS, REILLY, NAGARKATTI, PRAKASH S · 2012 to 2023
$20.7M
Use of Resveratrol to treat experimental multiple sclerosisP01AT003961 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, PRAKASH S · 2007 to 2018
$14.2M
Role of natural indoles in experimental autoimmune encephalomyelitisR01AT006888 · NCCIH · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI NAGARKATTI, MITZI · 2011 to 2015
$2.0M
NCCIH NIH HHS P01 AT003961NCCIH NIH HHS R01 AT006888NIGMS NIH HHS P20 GM103641
6 · The paper itself

Abstract

Glioma is the most common and believed to be one of the most aggressive tumors of the central nervous system (CNS) in humans. Very little information is available on the etiology and pathogenesis of these tumors to date. A significant gap remains in our current understanding of the molecular pathways involved in the genesis, progression and clinical behavior of these tumors. Recently, several single nucleotide polymorphisms (SNPs) have been identified in cytokine gene sequences, particularly within the promoter region of these genes, and have been shown to be associated with the development of different types of brain tumors. The present study investigates the association of C-33T SNP in the interleukin-4 (IL-4) gene with systemic IL-4 level and the S503P SNP in the IL-4R gene with the incidence of glioma. Blood samples were collected from 100 histologically confirmed adult patients with glioma, and 30 apparently healthy individuals from the same area. DNA was extracted from each blood sample, and the IL-4 and IL-4R genes were amplified using polymerase chain reaction (PCR) with gene-specific primers. Systemic IL-4 concentration was assessed in serum samples from each participant by enzyme-linked immunosorbent assay (ELISA). We observed a negative association between the homozygous genotype (CC) of the SNP C-33T of the IL-4 gene with the incidence of glioma (OR=0.19, 95% CI=0.035-1.02), while the T allele of the SNP demonstrated a significant protective association against glioma. Similarly, the heterozygous (CT) and homozygous mutant (CC) of the SNP S503P of the IL-4R gene demonstrated a significant association with glioma development (OR=0.405, 95% CI=0.17-0.969 and OR=0.147, 95% CI=0.036-0.6 respectively), while the C allele exhibited a highly significant association with protection from glioma formation. These findings suggest that the T allele of the SNP C-33T in the IL-4 gene and the C allele of the SNP S503P in IL-4R may have a protective role against glioma development.

Indexed as

AdolescentAdultAgedChildChild, PreschoolGenetic Predisposition to DiseaseGenotypeGliomaHumansIncidenceInterleukin-4IraqMiddle AgedPolymorphism, Single NucleotideReceptors, Interleukin-4Young AdultInterleukin-4Receptors, Interleukin-4and Gliomabrain tumorinterleukin-4interleukin-4RSingle nucleotide polymorphism (SNPs)

Identifiers

PMID25170298
PMCPMC4147641
OpenAlexW2109650976

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.