Evidence map›Paper›PMID 25170275›Full record

ReviewClinical and experimental gastroenterology2014

Diagnosis and management of microscopic colitis: current perspectives.

Johan Bohr, Anna Wickbom, Agnes Hegedus, Nils Nyhlin, Elisabeth Hultgren Hörnquist, Curt Tysk

Open access · goldAbstract readReview
In one paragraph

Review in Clinical and experimental gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Epidemiology of Microscopic Colitis in Olmsted County, Minnesota: Population-Based Study From 2011 to 2019.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Article
  8. Article
  9. Article
  10. Article
  11. Management of microscopic colitis: challenges and solutions.Clinical and experimental gastroenterology · 2019
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Microscopic colitis that is not so microscopic.International journal of colorectal disease · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Johan BohrDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden ; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Anna WickbomDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden ; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Agnes HegedusDepartment of Laboratory Medicine/Pathology, Örebro University Hospital, Örebro, Sweden.
Nils NyhlinDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden ; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Elisabeth Hultgren HörnquistSchool of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Curt TyskDivision of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden ; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro University · SEÖrebro University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagenous colitis and lymphocytic colitis, together constituting microscopic colitis, are common causes of chronic diarrhea. They are characterized clinically by chronic nonbloody diarrhea and a macroscopically normal colonic mucosa where characteristic histopathological findings are seen. Previously considered rare, they now have emerged as common disorders that need to be considered in the investigation of the patient with chronic diarrhea. The annual incidence of each disorder is five to ten per 100,000 inhabitants, with a peak incidence in 60- to 70-year-old individuals and a predominance of female patients in collagenous colitis. The etiology and pathophysiology are not well understood, and the current view suggests an uncontrolled mucosal immune reaction to various luminal agents in predisposed individuals. Clinical symptoms comprise chronic diarrhea, abdominal pain, fatigue, weight loss, and fecal incontinence that may impair the patient's health-related quality of life. An association is reported with other autoimmune disorders, such as celiac disease, thyroid disorders, diabetes mellitus, and arthritis. The best-documented treatment, both short-term and long-term, is budesonide, which induces clinical remission in up to 80% of patients after 8 weeks' treatment. However, after successful budesonide therapy is ended, recurrence of clinical symptoms is common, and the best possible long-term management deserves further study. The long-term prognosis is good, and the risk of complications, including colonic cancer, is low. We present an update of the epidemiology, pathogenesis, diagnosis, and management of microscopic colitis.

Indexed as

budesonidechronic diarrheacollagenous colitislymphocytic colitismicroscopic colitis

Identifiers

PMID25170275
PMCPMC4144984
OpenAlexW2092823242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.