Evidence map›Paper›PMID 25170266›Full record

ArticleInternational journal of nanomedicine2014

Local delivery of minocycline-loaded PEG-PLA nanoparticles for the enhanced treatment of periodontitis in dogs.

Wenxin Yao, Peicheng Xu, Zhiqing Pang, Jingjing Zhao, Zhilan Chai, Xiaoxia Li, Huan Li, Menglin Jiang, Hongbo Cheng, Bo Zhang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. [Efficacy of minocycline hydrochloride combined with flap surgery for chronic periodontitis: a Meta-analysis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018
    Pooled it
  2. Application of injectable hydrogels in the treatment of periodontitis.Frontiers in bioengineering and biotechnology · 2026
    Review
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  19. Engineering Polymeric Nanosystems against Oral Diseases.Molecules (Basel, Switzerland) · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wenxin YaoShanghai Xuhui District Dental Center, Fudan University, Shanghai, People's Republic of China.
Peicheng XuShanghai Xuhui District Dental Center, Fudan University, Shanghai, People's Republic of China.
Zhiqing PangKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Jingjing ZhaoKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Zhilan ChaiKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Xiaoxia LiDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Huan LiKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Menglin JiangKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Hongbo ChengKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Bo ZhangKey Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai, People's Republic of China ; Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Nengneng ChengDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai, People's Republic of China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRapid local drug clearance of antimicrobials is a major drawback for the treatment of chronic periodontitis. In the study reported here, minocycline-loaded poly(ethylene glycol)-poly(lactic acid) nanoparticles were prepared and administered locally for long drug retention and enhanced treatment of periodontitis in dogs.

methodsBiodegradable poly(ethylene glycol)-poly(lactic acid) was synthesized to prepare nanoparticles using an emulsion/solvent evaporation technique. The particle size and zeta potential of the minocycline-loaded nanoparticles (MIN-NPs) were determined by dynamic light scattering and the morphology of the nanoparticles was observed by transmission electron microscopy. The in vitro release of minocycline from MIN-NPs and in vivo pharmacokinetics of minocycline in gingival crevice fluid, after local administration of MIN-NPs in the periodontal pockets of beagle dogs with periodontitis, were investigated. The anti-periodontitis effects of MIN-NPs on periodontitis-bearing dogs were finally evaluated.

resultsTransmission electron microscopy examination and dynamic light scattering results revealed that the MIN-NPs had a round shape, with a mean diameter around 100 nm. The in vitro release of minocycline from MIN-NPs showed a remarkably sustained releasing characteristic. After local administration of the MIN-NPs, minocycline concentration in gingival crevice fluid decreased slowly and retained an effective drug concentration for a longer time (12 days) than Periocline(®). Anti-periodontitis effects demonstrated that MIN-NPs could significantly decrease symptoms of periodontitis compared with Periocline and minocycline solution. These findings suggest that MIN-NPs might have great potential in the treatment of periodontitis.

Indexed as

AnimalsAnti-Bacterial AgentsDisease Models, AnimalDogsDrug CarriersGingival Crevicular FluidLactatesMinocyclineParticle SizePeriodontal IndexPeriodontitisPolyethylene GlycolsRandom AllocationAnti-Bacterial AgentsDrug CarriersLactatesMinocyclinePolyethylene Glycolspoly(lactic acid-ethylene glycol)local deliveryminocyclinenanoparticlesperiodontitis

Identifiers

PMID25170266
PMCPMC4145825
OpenAlexW2029354948

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.