ReviewClinical interventions in aging2014
Use of atypical antipsychotics in the elderly: a clinical review.
Review in Clinical interventions in aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Gabapentin and pregabalin to treat aggressivity in dementia: a systematic review and illustrative case report.British journal of clinical pharmacology · 2019Pooled it
- Evaluation of the efficacy of randomized controlled trials of sensory stimulation interventions for sleeping disturbances in patients with dementia: a systematic review.Clinical interventions in aging · 2017Pooled it
- Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 6. Special Populations: Youth, Women, and the Elderly.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2016Pooled it
- Pimavanserin safety in adult and elderly patients with neuropsychiatric symptoms related to neurodegenerative disease: An open-label extension study.Journal of Alzheimer's disease : JAD · 2025Trial
- Antipsychotic prescribing and drug-related readmissions in multimorbid older inpatients: a post-hoc analysis of the OPERAM population.International journal of clinical pharmacy · 2024Trial
- Long-term antipsychotic use, orthostatic hypotension and falls in older adults with Alzheimer's disease.European geriatric medicine · 2024Trial
- Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.Anesthesiology · 2017Trial
- The Utilization of Robotic Pets in Dementia Care.Journal of Alzheimer's disease : JAD · 2017Trial
- Bipolar Disorder in Older Adults: A Comprehensive Overview of Pharmacotherapy Patterns and Clinical Considerations.Drugs & aging · 2026Review
- Cardiomyopathy Following Olanzapine Use in an Octogenarian: A Case Report and Literature Review.Cureus · 2026Article
- Prescribing and deprescribing of atypical antipsychotics in older multimorbid patients.BMC geriatrics · 2025Article
- Targeting Neurodegeneration with SGLT2is: From Molecular Mechanisms to Clinical Implications.Molecular neurobiology · 2025Review
- Influence of Ageing on the Pharmacodynamics and Pharmacokinetics of Chronically Administered Medicines in Geriatric Patients: A Review.Clinical pharmacokinetics · 2025Review
- Identifying dementia from cognitive footprints in hospital records among Chinese older adults: a machine-learning study.The Lancet regional health. Western Pacific · 2024Article
- Designing a tool ensuring older patients the right medication at the right time after discharge from hospital- the first step in a participatory design process.BMC health services research · 2024Article
- Medication Dosage Impact on Mortality in Old-Age Individuals with Schizophrenia: A National Cohort Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Falls in hospitalized older adults and the use of fall risk-increasing drugs and anticholinergic medications in Colombia: a case‒control study.Frontiers in pharmacology · 2024Article
- Long-Acting Injectable Antipsychotics-A Review on Formulation and In Vitro Dissolution.Pharmaceutics · 2023Review
- Adverse drug reactions in geriatric psychiatry-retrospective cohort study of a 6-year period.Irish journal of medical science · 2023Article
- Handling polypharmacy -a qualitative study using focus group interviews with older patients, their relatives, and healthcare professionals.BMC geriatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of atypical antipsychotic drugs in the elderly has become wider and wider in recent years; in fact, these agents have novel receptor binding profiles, good efficacy with regard to negative symptoms, and reduced extrapyramidal symptoms. However, in recent years, the use of both conventional and atypical antipsychotics has been widely debated for concerns about their safety in elderly patients affected with dementia and the possible risks for stroke and sudden death. A MEDLINE search was made using the words elderly, atypical antipsychotics, use, schizophrenia, psychosis, mood disorders, dementia, behavioral disorders, and adverse events. Some personal studies were also considered. This paper reports the receptor binding profiles and the main mechanism of action of these drugs, together with their main use in psychiatry and the possible adverse events in elderly people.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.