Evidence map›Paper›PMID 25170153›Full record

ArticleScience (New York, N.Y.)2014

Targeted enhancement of cortical-hippocampal brain networks and associative memory.

Jane X Wang, Lynn M Rogers, Evan Z Gross, Anthony J Ryals, Mehmet E Dokucu, Kelly L Brandstatt, Molly S Hermiller, Joel L Voss

9 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 309 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
309citing papers in PubMed, 9 pooled it
16.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03050801 phase1 / phase2completednot on this mapstarted 2017, after this paper: background citation

Functional Connectivity as a Biomarker of rTMS

TypeinterventionalSponsorNational Institute of Neurological Disorders and Stroke (NINDS)Ran2017 to 2020Enrolled68ConditionsTraumatic Brain InjuryArmsrTMS
NCT03406195 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Modulation of Episodic Memory Using Theta Burst Stimulation (TBS)

TypeinterventionalSponsorDuke UniversityRan2018 to 2019Enrolled0ConditionsAgingArmsTranscranial magnetic stimulation (TMS)
NCT03497884 nacompletednot on this mapstarted 2017, after this paper: background citation

Individualized Precise Localization of rTMS on Primary Motor Area and Its Effects on Basal Ganglia

TypeinterventionalSponsorHangzhou Normal UniversityRan2017 to 2018Enrolled38ConditionsParkinson DiseaseArmsrTMS
NCT03515408 nacompletednot on this mapstarted 2018, after this paper: background citation

Individualized Precise Localization of rTMS on Precentral and Parietal Gyrus and Its Effects on Dorsal Anterior Cingulate Cortex

TypeinterventionalSponsorHangzhou Normal UniversityRan2018 to 2018Enrolled32ConditionsAttention Deficit Hyperactivity DisorderArmsrTMS
NCT04081519 nacompletednot on this mapstarted 2016, after this paper: background citation

Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder

TypeinterventionalSponsorUniversity Hospital, BonnRan2016 to 2018Enrolled53ConditionsDepression, Depressive Disorder, Depressive Episode, Depressive Disorder, MajorArmsactive rTMS over DLPFC, Add-on active rTMS over DLPFC, Add-on active rTMS over LPC, Add-on sham rTMS
NCT04260724 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Prospective, Randomized, Evaluator-blind, Single Center Study on the Effect of Transcranial Magnetic Stimulation in Mild to Moderate Alzheimer's Disease

TypeinterventionalSponsorSamsung Medical CenterRan2020 to 2022Enrolled32ConditionsMild to Moderate Alzheimer DiseaseArmsTMS, sham coil stimulation
NCT04694131 nacompletednot on this mapstarted 2021, after this paper: background citation

Task-dependent Effects of TMS on the Neural Biomarkers of Episodic Memory

TypeinterventionalSponsorNational Institute of Neurological Disorders and Stroke (NINDS)Ran2021 to 2023Enrolled43ConditionsNormal PhysiologyArmsTMS
NCT05805215 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Noninvasive Temporal Interference Stimulation: An Approach for Modulating Associative Memory by Targeting Deep-brain Targets

TypeinterventionalSponsorMasaryk UniversityRan2024 to 2025Enrolled30ConditionsHealthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment, Alzheimer DiseaseArmsNon-invasive Temporal Interference stimulation and Face-name association training task targeting the hippocampus, Non-invasive Temporal Interference stimulation and Face-name association training task targeting the Precuneus, High-frequency stimulation (placebo) with Face-name association training task
NCT06538311 early_phase1recruitingnot on this mapstarted 2023, after this paper: background citation

Neuromodulation of Brain Function in Alzheimer's Disease and Related Dementias

TypeinterventionalSponsorMassachusetts General HospitalRan2023 to 2027Enrolled30ConditionsAlzheimer Disease, Mild Cognitive Impairment, Logopenic Progressive Aphasia, Amnestic SymptomsArmsActive rTMS, Sham rTMS
3 · Its place in the literature

Who cites it

309 citing papers in PubMed, 9 syntheses or guidelines pooled it, 630 citations in OpenAlex.

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249 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jane X WangDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Lynn M RogersThe Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL, USA.
Evan Z GrossDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Anthony J RyalsDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Mehmet E DokucuDepartment of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Kelly L BrandstattDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Molly S HermillerDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Joel L VossDepartment of Medical Social Sciences, Ken and Ruth Davee Department of Neurology, and Interdepartmental Neuroscience Program, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. joel-voss@northwestern.edu.
Northwestern University · USShirley Ryan AbilityLab · US

Funding

Prefrontal and Medial-Temporal Interactions in MemoryP50MH094263 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HASSELMO, MICHAEL E · 2011 to 2015
$8.7M
Function and dysfunction of brain networks for the flexible expression of memoryF32NS083340 · NINDS · NORTHWESTERN UNIVERSITY · PI WANG, XIAOJING · 2013 to 2015
$136k
NIMH NIH HHS P50 MH094263NIMH NIH HHS P50-MH094263NINDS NIH HHS F32 NS083340NINDS NIH HHS F32-NS083340
6 · The paper itself

Abstract

The influential notion that the hippocampus supports associative memory by interacting with functionally distinct and distributed brain regions has not been directly tested in humans. We therefore used targeted noninvasive electromagnetic stimulation to modulate human cortical-hippocampal networks and tested effects of this manipulation on memory. Multiple-session stimulation increased functional connectivity among distributed cortical-hippocampal network regions and concomitantly improved associative memory performance. These alterations involved localized long-term plasticity because increases were highly selective to the targeted brain regions, and enhancements of connectivity and associative memory persisted for ~24 hours after stimulation. Targeted cortical-hippocampal networks can thus be enhanced noninvasively, demonstrating their role in associative memory.

Indexed as

AssociationTranscranial Magnetic StimulationAdultFemaleHippocampusHumansMagnetic Resonance ImagingMaleMemoryNerve NetParietal LobeYoung Adult

Identifiers

PMID25170153
PMCPMC4307924
OpenAlexW2058860479

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.