ArticleBlood2014
Induction of fetal hemoglobin through enhanced translation efficiency of γ-globin mRNA.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease.Expert review of hematology · 2015Pooled it
- Allosteric disordering of eIF2B regulates the integrated stress response.Nature chemical biology · 2026Article
- Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- Innovations in Drug Discovery for Sickle Cell Disease Targeting Oxidative Stress and NRF2 Activation-A Short Review.International journal of molecular sciences · 2025Review
- Evaluation of Genes and Molecular Pathways Involved in Pathogenesis of Sickle Cell Anemia: A Bioinformatics Analysis and Future Perspective.Iranian journal of public health · 2024Article
- PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin.Blood advances · 2022Article
- Heme Causes Pain in Sickle MiceAntioxidants & redox signaling · 2021Article
- Whole Blood Transcriptome Analysis in Children with Sickle Cell Anemia.Frontiers in genetics · 2021Article
- Article
- HRI stress signaling and HbF production.Blood · 2020Article
- Global translational repression induced by iron deficiency in yeast depends on the Gcn2/eIF2α pathway.Scientific reports · 2020Article
- Proteomic Studies for the Investigation of γ-Globin Induction by Decitabine in Human Primary Erythroid Progenitor Cultures.Journal of clinical medicine · 2020Article
- Review
- Oxidative Stress in β-Thalassemia.Molecular diagnosis & therapy · 2019Review
- Mast Cells Induce Blood Brain Barrier Damage in SCD by Causing Endoplasmic Reticulum Stress in the Endothelium.Frontiers in cellular neuroscience · 2019Article
- Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells.Science (New York, N.Y.) · 2018Article
- ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in β-thalassaemia.Molecular genetics and genomics : MGG · 2018Article
- Article
- Pathophysiology and treatment of patients with beta-thalassemia - an update.F1000Research · 2017Review
- Original Research: Stable expression of miR-34a mediates fetal hemoglobin induction in K562 cells.Experimental biology and medicine (Maywood, N.J.) · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fetal hemoglobin (HbF) induction can ameliorate the clinical severity of sickle cell disease and β-thalassemia. We previously reported that activation of the eukaryotic initiation factor 2α (eIF2α) stress pathway increased HbF through a posttranscriptional mechanism. In this study, we explored the underlying means by which salubrinal, an activator of eIF2α signaling, enhances HbF production in primary human erythroid cells. Initial experiments eliminated changes in globin messenger RNA (mRNA) stability or cellular location and reduction of adult hemoglobin as possible salubrinal mechanisms. We then determined that salubrinal selectively increased the number of actively translating ribosomes on γ-globin mRNA. This enhanced translation efficiency occurred in the recovery phase of the stress response as phosphorylation of eIF2α and global protein synthesis returned toward baseline. These findings highlight γ-globin mRNA translation as a novel mechanism for regulating HbF production and as a pharmacologic target for induction of HbF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.