ArticleJournal of applied physiology (Bethesda, Md. : 1985)2014
Pendelluft in the bronchial tree.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Self-organized ventilation defects in asthma: insights and open-source implementation of the Venegas-Winkler model.Royal Society open science · 2026Article
- Effect of airway constriction on ventilation inhomogeneity: multiple-breath washout indices and intrapulmonary reverse flow.Respiratory research · 2026Article
- Chronic phase ventilation strategy in established severe bronchopulmonary dysplasia: A critical evaluation of the evidence.SAGE open medicine · 2026Review
- Simulation of Central Airway Gas Flow Dynamics During Conventional and Multifrequency Ventilation.Journal of biomechanical engineering · 2025Article
- Design and Implementation of a Computer-Controlled Hybrid Oscillatory Ventilator.Journal of medical devices · 2025Article
- Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study.Critical care (London, England) · 2025Article
- The Impact of PEEP on Ventilation Distribution in ARDS.Respiratory care · 2024Article
- Occurrence of pendelluft during ventilator weaning with T piece correlated with increased mortality in difficult-to-wean patients.Journal of intensive care · 2024Article
- Asymmetrical nasal high flow ventilation improves clearance of COJournal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Endotracheal tube, by the venturi effect, reduces the efficacy of increasing inlet pressure in improving pendelluft.PloS one · 2023Article
- Mechanisms of airway remodeling converge at the critical point of bronchoconstriction in asthma.Annals of translational medicine · 2022Article
- Gas Exchange Mechanism of High Frequency Ventilation: A Brief Narrative Review and Prospect.Journal of Shanghai Jiaotong University (science) · 2022Article
- Reverse Triggering: An Introduction to Diagnosis, Management, and Pharmacologic Implications.Frontiers in pharmacology · 2022Review
- Impaired pulmonary ventilation beyond pneumonia in COVID-19: A preliminary observation.PloS one · 2022Article
- [Prospects and developments in the technologies of high frequency oscillatory ventilation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Breathing freely during nitrogen washout.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Magentic Resonance Imaging Evaluation of Regional Lung Vts in Severe Neonatal Bronchopulmonary Dysplasia.American journal of respiratory and critical care medicine · 2020Article
- Occurrence of pendelluft under pressure support ventilation in patients who failed a spontaneous breathing trial: an observational study.Annals of intensive care · 2020Article
- Inspiratory Efforts, Positive End-Expiratory Pressure, and External Resistances Influence Intraparenchymal Gas Redistribution in Mechanically Ventilated Injured Lungs.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Inhomogeneous inflation or deflation of the lungs can cause dynamic pressure differences between regions and lead to interregional airflows known as pendelluft. This work first uses analytical tools to clarify the theoretical limits of pendelluft at a single bifurcation. It then explores the global and regional pendelluft that may occur throughout the bronchial tree in a realistic example using an in silico model of bronchoconstriction. The theoretical limits of pendelluft volume exchanged at a local bifurcation driven by sinusoidal breathing range from 15.5% to 41.4% depending on the relative stiffness of the subtended regions. When nonsinusoidal flows are considered, pendelluft can be as high as 200% inlet tidal volume (Vin). At frequencies greater than 10 Hz, the inertia of the air in the airways becomes important, and the maximal local pendelluft is theoretically unbounded, even with sinusoidal breathing. In a single illustrative numerical simulation of bronchoconstriction with homogenous compliances, the overall magnitude of global pendelluft volume was <2% of the tidal volume. Despite the small overall magnitude, pendelluft volume exchange was concentrated in poorly ventilated regions of the lung, including local pendelluft at bifurcations of up to 13% Vin. This example suggests that pendelluft may be an important phenomena contributing to regional gas exchange, irreversible mixing, and aerosol deposition patterns inside poorly ventilated regions of the lung. The analytical results support the concept that pendelluft may be more prominent in diseases with significant heterogeneity in both resistance and compliance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.