ArticleGenome biology and evolution2014
Gene transfers shaped the evolution of de novo NAD+ biosynthesis in eukaryotes.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Trial
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- Metagenomic insights into Heimdallarchaeia clades from the deep-sea cold seep and hydrothermal vent.Environmental microbiome · 2024Article
- Nicotinamide pathways as the root cause of sepsis - an evolutionary perspective on macrophage energetic shifts.The FEBS journal · 2022Review
- Convergent Evolution of Himalayan Marmot with Some High-Altitude Animals through ND3 Protein.Animals : an open access journal from MDPI · 2021Article
- The Kynurenine Pathway in Acute Kidney Injury and Chronic Kidney Disease.American journal of nephrology · 2021Review
- The genome of Prasinoderma coloniale unveils the existence of a third phylum within green plants.Nature ecology & evolution · 2020Article
- The 4 D's of Pellagra and Progress.International journal of tryptophan research : IJTR · 2020Review
- Casting light on Asgardarchaeota metabolism in a sunlit microoxic niche.Nature microbiology · 2019Article
- Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?International journal of tryptophan research : IJTR · 2019Review
- De novo NADNature medicine · 2018Article
- Phytohormone sensing in the biotrophic fungus Ustilago maydis - the dual role of the transcription factor Rss1.Molecular microbiology · 2016Article
- The NAD(+) salvage pathway modulates cancer cell viability via p73.Cell death and differentiation · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
NAD(+) is an essential molecule for life, present in each living cell. It can function as an electron carrier or cofactor in redox biochemistry and energetics, and serves as substrate to generate the secondary messenger cyclic ADP ribose and nicotinic acid adenine dinucleotide phosphate. Although de novo NAD(+) biosynthesis is essential, different metabolic pathways exist in different eukaryotic clades. The kynurenine pathway starting with tryptophan was most likely present in the last common ancestor of all eukaryotes, and is active in fungi and animals. The aspartate pathway, detected in most photosynthetic eukaryotes, was probably acquired from the cyanobacterial endosymbiont that gave rise to chloroplasts. An evolutionary analysis of enzymes catalyzing de novo NAD(+) biosynthesis resulted in evolutionary trees incongruent with established organismal phylogeny, indicating numerous gene transfers. Endosymbiotic gene transfers probably introduced the aspartate pathway into eukaryotes and may have distributed it among different photosynthetic clades. In addition, several horizontal gene transfers substituted eukaryotic genes with bacterial orthologs. Although horizontal gene transfer is accepted as a key mechanism in prokaryotic evolution, it is supposed to be rare in eukaryotic evolution. The essential metabolic pathway of de novo NAD(+) biosynthesis in eukaryotes was shaped by numerous gene transfers.
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