Evidence map›Paper›PMID 25169927›Full record

ArticleAJNR. American journal of neuroradiology2015

Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury.

A Tekes, A Poretti, M M Scheurkogel, T A G M Huisman, J A Howlett, E Alqahtani, J-H Lee, C Parkinson, K Shapiro, S-E Chung and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Review
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  7. Observational
  8. Review
  9. Observational
  10. Article
  11. Bedside and laboratory neuromonitoring in neonatal encephalopathy.Seminars in fetal & neonatal medicine · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

A TekesFrom the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) atekes1@jhmi.edu.
A PorettiFrom the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.).
M M ScheurkogelFrom the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology.
T A G M HuismanFrom the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology Neurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.).
J A HowlettNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics.
E AlqahtaniFrom the Division of Pediatric Radiology and Pediatric Neuroradiology (A.T., A.P., M.M.S., T.A.G.M.H., E.A.), Department of Radiology.
J-H LeeDepartment of Anesthesiology and Critical Care Medicine (J.-H.L., C.W.H., R.C.K.).
C ParkinsonNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics.
K ShapiroNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics.
S-E ChungDivision of General Pediatrics and Adolescent Medicine (S.-E.C., J.M.J.), Department of Pediatrics Center for Child and Community Health Research (S.-E.C., J.M.J., J.K.L.).
J M JenningsDivision of General Pediatrics and Adolescent Medicine (S.-E.C., J.M.J.), Department of Pediatrics Center for Child and Community Health Research (S.-E.C., J.M.J., J.K.L.).
M M GilmoreNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics.
C W HogueDepartment of Anesthesiology and Critical Care Medicine (J.-H.L., C.W.H., R.C.K.).
L J MartinDivision of Neuropathology (L.J.M.), Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
R C KoehlerDepartment of Anesthesiology and Critical Care Medicine (J.-H.L., C.W.H., R.C.K.).
F J NorthingtonNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Division of Neonatology, (J.A.H., C.P., K.S., M.M.G., F.J.N.), Department of Pediatrics.
J K LeeNeurosciences Intensive Care Nursery Program (A.T., A.P., T.A.G.M.H, J.A.H., C.P., K.S., M.M.G., F.J.N., J.K.L.) Center for Child and Community Health Research (S.-E.C., J.M.J., J.K.L.).
United States Nuclear Regulatory Commission · USOffice of Adolescent Health · US

Funding

Therapeutic Strategies for Neonatal Hypoxic-Ischemiic EncephalopathyR01NS060703 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOEHLER, RAYMOND CHARLES · 2008 to 2019
$3.9M
Continuous Cerebral Autoregulation Monitoring to Reduce Brain Injury from CardiacR01HL092259 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOGUE, CHARLES W · 2009 to 2018
$3.4M
Mechanisms of Hypothermic Neuroprotection in NeonatesR01HD070996 · NICHD · JOHNS HOPKINS UNIVERSITY · PI NORTHINGTON, FRANCES J · 2012 to 2016
$1.7M
Neuronal injury after pediatric cardiac arrest, hypothermia, and rewarmingK08NS080984 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LEE, JENNIFER KIM · 2014 to 2018
$960k
NHLBI NIH HHS R01 HL092259NHLBI NIH HHS R01HL092259NICHD NIH HHS HD070996NICHD NIH HHS R01 HD070996NINDS NIH HHS K08 NS080984NINDS NIH HHS NS060703NINDS NIH HHS R01 NS060703
6 · The paper itself

Abstract

background and purposeNeurologic morbidity remains high in neonates with perinatal hypoxic-ischemic injury despite therapeutic hypothermia. DTI provides qualitative and quantitative information about the microstructure of the brain, and a near-infrared spectroscopy index can assess cerebrovascular autoregulation. We hypothesized that lower ADC values would correlate with worse autoregulatory function. MATERIALS AND

methodsThirty-one neonates with hypoxic-ischemic injury were enrolled. ADC scalars were measured in 27 neonates (age range, 4-15 days) in the anterior and posterior centrum semiovale, basal ganglia, thalamus, posterior limb of the internal capsule, pons, and middle cerebellar peduncle on MRI obtained after completion of therapeutic hypothermia. The blood pressure range of each neonate with the most robust autoregulation was identified by using a near-infrared spectroscopy index. Autoregulatory function was measured by blood pressure deviation below the range with optimal autoregulation.

resultsIn neonates who had MRI on day of life ≥10, lower ADC scalars in the posterior centrum semiovale (r = -0.87, P = .003, n = 9) and the posterior limb of the internal capsule (r = -0.68, P = .04, n = 9) correlated with blood pressure deviation below the range with optimal autoregulation during hypothermia. Lower ADC scalars in the basal ganglia correlated with worse autoregulation during rewarming (r = -0.71, P = .05, n = 8).

conclusionsBlood pressure deviation from the optimal autoregulatory range may be an early biomarker of injury in the posterior centrum semiovale, posterior limb of the internal capsule, and basal ganglia. Optimizing blood pressure to support autoregulation may decrease the risk of brain injury in cooled neonates with hypoxic-ischemic injury.

Indexed as

Blood PressureBrainBrain InjuriesCerebrovascular CirculationFemaleHomeostasisHumansHypothermia, InducedHypoxia-Ischemia, BrainInfant, NewbornMagnetic Resonance ImagingMaleSpectroscopy, Near-Infrared

Identifiers

PMID25169927
PMCPMC4359612
OpenAlexW2042423837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.