ArticleMolecular and cellular biochemistry2014
Knockdown of NOB1 expression inhibits the malignant transformation of human prostate cancer cells.
Article in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- scTIGER: A Deep-Learning Method for Inferring Gene Regulatory Networks from Case versus Control scRNA-seq Datasets.International journal of molecular sciences · 2023Article
- miRNA-612 suppresses ovarian cancer cell tumorigenicity by downregulating NOB1.American journal of translational research · 2022Article
- MiR-363 suppresses cell migration, invasion, and epithelial-mesenchymal transition of osteosarcoma by binding to NOB1.World journal of surgical oncology · 2020Observational
- LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis.Frontiers in pharmacology · 2019Article
- microRNA-744 is downregulated in glioblastoma and inhibits the aggressive behaviors by directly targeting NOB1.American journal of cancer research · 2018Article
- Low-level miR-646 in colorectal cancer inhibits cell proliferation and migration by targeting NOB1 expression.Oncology letters · 2017Article
- MicroRNA-363 inhibits ovarian cancer progression by inhibiting NOB1.Oncotarget · 2017Article
- MicroRNA-215 targets NOB1 and inhibits growth and invasion of epithelial ovarian cancer.American journal of translational research · 2017Article
- Anticancer activity of NOB1-targeted shRNA combination with TRAIL in epithelial ovarian cancer cells.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
- Expression of concern
Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nin one binding-1 protein (NOB1) is a kind of zinc protein involved in ribosome biogenesis and controlled proteolysis. To explore the function of NOB1 in human prostate malignancy, we analyzed the expression of NOB1 in prostate cancer and found that NOB1 was elevated in prostate cancer tissues compared to the adjacent normal tissues. Knockdown of NOB1 by lentivirus-shRNA inhibited the proliferation and colony-formation ability of PC-3 and DU145 prostate cancer cells. Cell cycle analysis showed that silencing of NOB1 caused G0/G1 phase arrest and a slight decrease in S phase (P < 0.05). Furthermore, knockdown of NOB1 significantly suppressed the mobility of PC-3 and DU145 prostate cancer cells (P < 0.05). Collectively, these findings suggested that NOB1 might be involved in tumorigenecity of prostate cancer, and could be a potential molecular target for prostate cancer gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.