ArticlePhysiological reports2014
Early postnatal rat ventricle resection leads to long-term preserved cardiac function despite tissue hypoperfusion.
Article in Physiological reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Epicardial EMT and cardiac repair: an update.Stem cell research & therapy · 2024Review
- Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart.Developmental biology · 2024Review
- Animal models to study cardiac regeneration.Nature reviews. Cardiology · 2024Review
- A modified apical resection model with high accuracy and reproducibility in neonatal mouse and rat hearts.NPJ Regenerative medicine · 2023Article
- Heart regeneration: 20 years of progress and renewed optimism.Developmental cell · 2022Review
- Endocrine Influence on Cardiac Metabolism in Development and Regeneration.Endocrinology · 2021Review
- Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Vertebrate cardiac regeneration: evolutionary and developmental perspectives.Cell regeneration (London, England) · 2021Review
- A Brief History in Cardiac Regeneration, and How the Extra Cellular Matrix May Turn the Tide.Frontiers in cardiovascular medicine · 2021Review
- Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration.Seminars in cell & developmental biology · 2020Review
- Article
- Stage-dependent cardiac regeneration inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Neonatal Heart Regeneration: Comprehensive Literature Review.Circulation · 2018Article
- Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism.Scientific reports · 2017Article
- Evolution, comparative biology and ontogeny of vertebrate heart regeneration.NPJ Regenerative medicine · 2016Review
- Neonatal heart regeneration: mounting support and need for technical standards.Journal of the American Heart Association · 2015Article
- The type of injury dictates the mode of repair in neonatal and adult heart.Journal of the American Heart Association · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One-day-old mice display a brief capacity for heart regeneration after apex resection. We sought to examine this response in a different model and to determine the impact of this early process on long-term tissue perfusion and overall cardiac function in response to stress. Apical resection of postnatal rats at day 1 (P1) and 7 (P7) rendered 18 ± 1.0% and 16 ± 1.3% loss of cardiac area estimated by magnetic resonance imaging (MRI), respectively (P > 0.05). P1 was associated with evidence of cardiac neoformation as indicated by Troponin I and Connexin 43 expression at 21 days postresection, while in the P7 group mainly scar tissue replacement ensued. Interestingly, there was an apparent lack of uniform alignment of newly formed cells in P1, and we detected cardiac tissue hypoperfusion for both groups at 21 and 60 days postresection using SPECT scanning. Direct basal cardiac function at 60 days, when the early lesion is undetectable, was preserved in all groups, whereas under hemodynamic stress the degree of change on LVDEP, Stroke Volume and Stroke Work indicated diminished overall cardiac function in P7 (P < 0.05). Furthermore, the End-Diastolic Pressure-Volume relationship and increased interstitial collagen deposition in P7 is consistent with increased chamber stiffness. Taken together, we provide evidence that early cardiac repair response to apex resection in rats also leads to cardiomyocyte neoformation and is associated to long-term preservation of cardiac function despite tissue hypoperfusion.
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