Evidence map›Paper›PMID 25168313›Full record

ArticleScientific reports2014

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice.

M H Dijkstra, E Pirinen, J Huusko, R Kivelä, D Schenkwein, K Alitalo, S Ylä-Herttuala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Endothelial Lipid Metabolism.Cold Spring Harbor perspectives in medicine · 2022
    Review
  6. Review
  7. Article
  8. Article
  9. Angiogenesis and angiocrines regulating heart growth.Vascular biology (Bristol, England) · 2020
    Review
  10. Article
  11. VEGF-B is a potent antioxidant.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  12. Article
  13. Article
  14. Vascular Endothelial Growth Factor B and Its Signaling.Frontiers in cardiovascular medicine · 2018
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Vascular heterogeneity and specialization in development and disease.Nature reviews. Molecular cell biology · 2017
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

M H DijkstraDepartment of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, FIN-70211 Kuopio, Finland.
E Pirinen1] Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, FIN-70211 Kuopio, Finland [2].
J HuuskoDepartment of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, FIN-70211 Kuopio, Finland.
R KiveläWihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FIN-00290 Helsinki, Finland.
D SchenkweinDepartment of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, FIN-70211 Kuopio, Finland.
K AlitaloWihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, FIN-00290 Helsinki, Finland.
S Ylä-Herttuala1] Department of Biotechnology and Molecular Medicine, A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O.Box 1627, FIN-70211 Kuopio, Finland [2] Science Service Centre, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland [3] Gene Therapy Unit, Kuopio University Hospital, P.O. Box 1777, FIN-70211 Kuopio, Finland.
University of Eastern Finland · FIWihuri Research Institute · FIKuopio University Hospital · FI

Funding

European Research Council 268804
6 · The paper itself

Abstract

Vascular endothelial growth factor-B (VEGF-B) has been implicated to play a significant role in coronary vessel growth and endothelial uptake and transport of fatty acids in heart and skeletal muscle. Additionally, recent studies have shown that Vegf-b deficiency protects from high-fat diet (HFD)-induced diabetes and insulin resistance. We compared the cardiac function and the effects of HFD on body composition and glucose metabolism in two available Vegf-b knockout (Vegf-b(-/-) strains) mouse strains side by side with their respective littermate controls. We found no differences in HFD-induced weight gain, glucose tolerance or insulin resistance between the Vegf-b(-/-) strains and their littermate control mice. Furthermore, there was no difference in basal cardiac function and cardiac expression of genes involved in glucose or fatty acid metabolism between the Vegf-b(-/-) strains and their littermate control mice. We conclude that VEGF-B is dispensable for normal cardiac function under unstressed conditions and for HFD-induced metabolic changes.

Indexed as

AnimalsCardiovascular DiseasesDiet, High-FatGene ExpressionGene Knockout TechniquesMaleMice, Inbred C57BLMice, KnockoutPhenotypeTranscriptomeVascular Endothelial Growth Factor BVascular Endothelial Growth Factor Bvascular endothelial growth factor B, mouse

Identifiers

PMID25168313
PMCPMC4148648
OpenAlexW2057229488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.