ArticleJournal of burn care & research : official publication of the American Burn Association
Pulsed electric fields for burn wound disinfection in a murine model.
Article in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Electroporation-Based Biopsy Treatment Planning with Numerical Models and Tissue Phantoms.Annals of biomedical engineering · 2024Article
- A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.Advanced materials (Deerfield Beach, Fla.) · 2023Article
- High-Voltage, Pulsed Electric Fields EliminateAdvances in wound care · 2021Article
- Differential Cell Death and Regrowth of Dermal Fibroblasts and Keratinocytes After Application of Pulsed Electric Fields.Bioelectricity · 2020Article
- What Are the Effects of Irreversible Electroporation on a Staphylococcus aureus Rabbit Model of Osteomyelitis?Clinical orthopaedics and related research · 2019Article
- Low concentrations of acetic and formic acids enhance the inactivation of Staphylococcus aureus and Pseudomonas aeruginosa with pulsed electric fields.BMC microbiology · 2019Article
- Selective Inactivation ofAdvances in wound care · 2019Article
- Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study.Scientific reports · 2018Article
- Induction of Different Sensitization Patterns of MRSA to Antibiotics Using Electroporation.Molecules (Basel, Switzerland) · 2018Article
- Measuring the potential energy barrier to lipid bilayer electroporation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Preventing Scars after Injury with Partial Irreversible Electroporation.The Journal of investigative dermatology · 2016Article
- Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns.Biomaterials · 2016Article
- Imaging the dynamics of individual electropores.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Eradication of multidrug-resistant pseudomonas biofilm with pulsed electric fields.Biotechnology and bioengineering · 2016Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Emerging bacterial resistance renders many antibiotics ineffective, making alternative strategies of wound disinfection important. Here the authors report on a new, physical burn wound disinfection method: pulsed electric fields (PEFs). High voltage, short PEFs create nonthermal, permanent damage to cell membranes, possibly by irreversible electroporation. In medicine, PEF technology has recently been used for nonthermal ablation of solid tumors. The authors have expanded the spectrum of PEF applications in medicine to burn wound disinfection. A third-degree burn was induced on the dorsal skin of C57BL/6 mice. Immediately after the injury, the burn wound was infected with Acinetobacter baumannii expressing the luxCDABE operon. Thirty minutes after infection, the infected areas were treated with 80 pulses delivered at 500 V/mm, 70 μs, 1 Hz. The authors used bioluminescence to quantify bacteria on skin. Three animals were used for each experimental condition. PEFs were effective in the disinfection of infected burned murine skin. The bacterial load reduction correlated with the number of delivered pulses. Forty pulses of 500 V/mm led to a 2.04 ± 0.29 Log10 reduction in bacterial load; 80 pulses led to the immediate 5.53 ± 0.30 Log10 reduction. Three hours after PEF, the bacterial reduction of the skin treated with 500 V/mm, 80 pulses was 4.91 ± 0.71 Log10. The authors introduce a new method of wound disinfection using high voltage, short PEFs. They believe that PEF technology may represent an important alternative to antibiotics in addressing bacterial contamination of wounds, particularly those contaminated with multidrug-resistant bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.