Evidence map›Paper›PMID 25167077›Full record

ArticleJournal of dietary supplements2015

Evaluation of the Aromatase Inhibition Potential of Freeze-Dried Grape Powder.

Summer V Allen, Sandhya Pruthi, Vera J Suman, Tanya L Hoskin, Celine M Vachon, James N Ingle, Janet E Olson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dietary supplements, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Summer V Allena 1 Family Medicine Department , Mayo Clinic College of Medicine Rochester, Minnesota, USA.
Sandhya Pruthib 2 General Internal Medicine Department , Mayo Clinic College of Medicine Rochester, Minnesota, USA.
Vera J Sumanc 3 Health Sciences Research Department , Mayo Clinic College of Medicine Rochester, Minnesota, USA.
Tanya L Hoskind 4 Biomedical Statistics and Informatics Department , Mayo Clinic Rochester, Minnesota, USA.
Celine M Vachonc 3 Health Sciences Research Department , Mayo Clinic College of Medicine Rochester, Minnesota, USA.
James N Inglee 5 Department of Oncology , Mayo Clinic College of Medicine Rochester, Minnesota, USA.
Janet E Olsonc 3 Health Sciences Research Department , Mayo Clinic College of Medicine Rochester, Minnesota, USA.

Funding

The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
NCI NIH HHS P50 CA116201
6 · The paper itself

Abstract

objectiveTo determine the role of freeze-dried grapes as a potential aromatase inhibitor by testing of plasma hormone levels.

methodsA six-week study was conducted involving postmenopausal women during which 94 g of freeze-dried grape powder was consumed in addition to their usual diet. Plasma hormones were measured before and after the treatment.

resultsOf the 18 women involved in the study, average age and body mass index were 61.4 years and 24.4 respectively. For the hormone levels studied, the following median (interquartile range) percentage changes from baseline to six-week values were found: estradiol +11.8% (-34.4%, +44.2%), p = .42; estrone +3.4% (-15.7%, +12.9%), p = .64; estrone sulfate +5.3% (-19.9%, +56.3%), p = .35; testosterone -1.5% (-14.7%, +10.7%), p = .97; and androstenedione +12.6% (-17.1%, +49.1%), p = .15. The hormone levels did not significantly change between baseline and six weeks. Further, the changes that were observed did not tend to go in the hypothesized direction (estrogens and conjugates increased slightly, and testosterone decreased slightly). Only androstenedione showed a trend toward change in the hypothesized direction.

conclusionsIn this study, there was no evidence that plasma hormone levels are altered by six weeks of daily consumption of 94 g of freeze-dried grape powder.

Indexed as

biobankingbreast cancerepidemiologygrape seed extract

Identifiers

PMID25167077
PMCPMC4873455

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.